Research Studies: Huntington's Disease

Dr. Jody Corey-Bloom and her team are conducting several studies. For information, call 858-246-1254.

• PBT2 Trial (Reach HD), a multi-center research study to assess the safety and tolerability of PBT2 compared to a placebo taken over 6 months in subjects with early to mid-stage Huntington’s disease (HD). The study will also measure whether there is an effect on cognitive abilities, as well as other HD symptoms including movement and overall functioning.
• SEN0014196 Trial, a multi-center research study to determine the effect of food on the pharmacokinetics (PK) of SEN0014196 in subjects with early to mid-stage HD and explore potential biomarkers for use in Phase 2/3 studies.
• Assessment of basal ganglia signaling pathways affected in Huntington’s disease. They are conducting a single-center, observational study designed to investigate neural signaling pathways involved in cognitive and behavioral control through the use of single-pulse Transcranial Magnetic Stimulation (TMS). Eligible subjects include non-HD control subjects, pre-manifest HD, and early manifest HD subjects.
• Prospective memory deficits in Huntington’s disease. They are conducting a single-center, observational study designed to identify a fundamental, yet relatively unexamined, memory deficit that may affect the execution of various daily living skills in individuals diagnosed with HD.