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Adult Down Syndrome Clinic

The occurrence of Alzheimer's disease among adults with Down syndrome causes much concern for their families and care providers. Alzheimer’s disease is a progressive neurodegenerative disease of the brain that affects all aspects of cognition, including memory, language and problem solving.

Research has found that all adults with Down syndrome over the age of 40 develop plaques and tangles in their brains similar to those seen in persons with Alzheimer's disease. Based on this information, many parents and professionals often conclude that all persons with Down syndrome will eventually develop Alzheimer's disease.

Our goal is to better understand if this is seen clinically, and if so, to understand how and why it happens, and to develop treatments to halt it. See the UC San Diego Down Syndrome Center for Research and Treatment

What We Offer

UC San Diego serves as a regional resource for adults with Down syndrome and their families, caregivers, health care professionals, and others who share in our dedication to helping this population live happier and healthier lives.

Our multidisciplinary clinic is designed to evaluate persons with Down syndrome who are declining in cognitive function and potentially developing Alzheimer's disease, and to provide definitive diagnosis and offer treatment, including access to clinical trials.

We use the latest technologies to identify the earliest signs of Alzheimer’s disease, including brain imaging and cerebrospinal fluid analysis, as well as cognitive testing in adult patients with Down syndrome.

We also offer access to new therapies that are being developed to treat Alzheimer’s disease in these patients.

For information or to make an appointment, contact:

Adult Down Syndrome Center
Perlman Clinic
9350 Campus Point Drive
La Jolla, CA 92037
Phone: 858-657-8540
Fax: 858-657-8557

Related Research Programs

Related Faculty


Related Videos 
Brain 

Down Syndrome Center for Research and Treatment at UC San Diego with William Mobley.

Memory disorders and Alzheimer's Disease with Drs. Michael Rafii, director of the Adult Down Syndrome Clinic, and William Mobley, chair of the Department of Neurosciences.

UC San Diego -TV program on The translation gap and William Mobley's research on Down syndrome and Alzheimer's disease.

New findings in Down syndrome and Alzheimers disease (with William Mobley and researcher Steve Wagner)