Participate in a HD Clinical Trial or Study

Clinical Trials

Vaccinex

A Phase 2, Multi-center, Randomized, Double-blind, Placebo Controlled Study in Subjects With Late Prodromal and Early Manifest Huntington Disease (HD) to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of VX15/2503
ENROLLING NOW: The purpose of this study is to assess the safety and efficacy of monthly IV administration of a single dosage of VX15/2503 in Huntington's disease.

Teva

A Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Laquinimod (0.5, 1.0 and 1.5 mg/day) as Treatment in Patients with Huntington's Disease
ENROLLING NOW: The purpose of this study is to assess the efficacy and safety of different doses of laquinimod in Huntington's disease.

Omeros

Phase 2 Randomized, Double-Blind, Placebo-Controlled, Sequential, Cohort Study to Evaluate Safety and Efficacy of OMS643762 in Subjects with Huntington’s Disease
ENROLLMENT CLOSED: The purpose of this study is to determine the safety, tolerability and pharmacokinetics of OMS643762 (the study drug) in subjects with Huntington's disease.

Teva

A Phase 2, Dose-Finding, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Study, Evaluating the Safety and Efficacy of Pridopidine 45 mg, 67.5 mg, 90 mg, and 112.5 mg Twice-Daily Versus Placebo for Symptomatic Treatment in Patients With Huntington's Disease
ENROLLMENT CLOSED: The purpose of this study is to compare the efficacy and safety of different doses of pridopidine in the treatment of motor impairment in Huntington's disease.

Reach2HD

A randomized, double-blind, placebo-controlled study to assess the safety and tolerability, and efficacy of PBT2 in patients with early to mid-stage Huntington disease.
STUDY COMPLETED

Siena

Open-label Food Effect Study With SEN0014196 in Subjects With Huntington’s Disease
STUDY COMPLETED


Observational Trials

Enroll-HD

Enroll-HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
ENROLLING NOW: A longitudinal, observational, multinational study that will integrate two existing Huntington's Disease (HD) registries, REGISTRY in Europe and COHORT in North America and Australia, while also expanding to include sites in Latin America and Asia. With no end date and annual assessments, the goal of Enroll-HD is to build a large and rich database of longitudinal clinical information and biospecimens. This database will serve as a basis for future studies aimed at developing tools and biomarkers for progression and prognosis, identifying clinically relevant phenotypic characteristics, and establishing clearly defined endpoints for interventional studies.

COHORT

Cooperative Huntington’s Observational Research Trial (COHORT)
ENROLLMENT CLOSED


Experimental Studies

Estimating Huntington's Disease Onset Using a Low-Cost Balance Assessment
ENROLLING NOW: A single-center, observational study designed to enhance estimate of Huntington's disease onset using a simple and practical body sway assessment device (i.e. Wii Balance Board). A brief balance assessment will be administered to subjects with HD, at-risk for HD, and non-HD control subjects. Participation will require one visit. The study will be conducted at UCSD.

Prospective Memory Deficits in Huntington’s Disease
ENROLLING NOW: A single-center, observational study designed to identify a fundamental, yet relatively unexamined, memory deficit that may affect the execution of various daily living skills in individuals diagnosed with HD. A paper-and-pencil prospective memory task will be administered to subjects with early manifest HD and non-HD control subjects. Eligible subjects will be between the ages of 35 and 75. Participation will require one visit. The study will be conducted at UCSD. Approximately 40 subjects will be enrolled.  

Reaction Time in Huntington’s Disease Using the Computer Test of Information Processing
ENROLLING NOW: A single-center, observational study designed to identify reaction time deficits that may be associated with individuals diagnosed with HD. A computerized reaction time task will be administered to subjects with diagnosed with HD, at-risk for HD, and non-HD control subjects. The study will be conducted at UCSD.

Temporal Order Memory Deficits in Huntington’s Disease
ENROLLING NOW:  A single-center, observational study designed to identify a processing deficit that may affect the execution of various daily living skills in individuals diagnosed with HD. A computerized visuospatial temporal order memory task will be administered to subjects with early manifest HD and non-HD control subjects. Eligible subjects will be between the ages of 35 and 75. Participation will require one visit. The study will be conducted at UCSD. Approximately 40 subjects will be enrolled.

Assessment of Basal Ganglia Signaling Pathways Affected in Huntington’s Disease
STUDY COMPLETED

 
Clinical trials and studies information is updated periodically, so there is the potential that a trial listed as open on this site may no longer be open. Similarly, there may be trials available in addition to those listed here.

Please contact us at (858) 249-0568 or sup035@ucsd.edu to confirm clinical trial or study availability and/or to get further information about specific trials or studies.