Dr. Litvan is studying the applicable uses of a sticker sensor called epidermal electronic system (EES) sensor. There are three uses currently being studied:
This sub-study is studying if this sticker sensor can be used to find out more about processing in the brain. The sticker sensor will be placed on the forehead and be connected to a portable EEG to measure their brain waves while viewing visual stimulus on a computer screen and/or listening to auditory stimulus. Patients may be asked to take this system home and complete 15 minutes of testing a day for a week. Currently enrolling.
Prior studies have demonstrated a hyper-activation of a laryngeal muscle at rest in patients with PSP with needle-based EMG. This sub-study is studying if this EES sticker sensor and standard transcutaneous EMG electrodes can replicate this study in a non-invasive manner. During this study, the sticker sensor will be placed on the throat to record muscle activation while the subject is making different phonations. Currently enrolling.
For more information on this study, please contact (858) 822-MOVE or email email@example.com.
Familial PSP Study
This research study is hoping to identify gene variation involved
in PSP. Patients diagnosed with PSP and who have a living blood relative with a
neurological or psychological disorder may be eligible for this study. For more information on this study, please contact (858) 822-MOVE or email firstname.lastname@example.org.
Phase I Multiple Dose BMS Antibody Treatment
In collaboration with Bristol-Myers Squibb, Dr. Litvan is recruiting for a clinical trial to evaluate whether multiple doses of an investigational drug called BMS-986168 given intravenously over a course of about 6 months is safe and well-tolerated in subjects with PSP. BMS-986168 is an immunotherapy (antibody) drug designed to bind to and remove the free eTau (extracellular tau), which is believed to build up to abnormally high levels in the brains of subjects with PSP. Patients with PSP between 50 - 85 years of age who are able to walk with minimal assistance, willing to undergo 3 lumbar punctures (LPs) and 3 MRI scans, and have an available study partner may be eligible for this study. This study has open label extension continuation (not placebo-controlled) study available for patients after completion of the initial study. For more information on this study, please contact (858) 822-MOVE or email email@example.com.
Enrollment on hold
Postural Stability in PSP
Drs. Litvan and medical Student Danielle Gillard are studying postural stability in patients with PSP using an iPAD application. Eligible patients should be between 40-90 years of age, able to stand comfortably for 5 minutes unaided, and have no memory problems. For more information, please call (858) 822-MOVE or email firstname.lastname@example.org. Estimated start date May 2016.
Validation of new MDS PD Diagnostic Criteria
This study is validating new Parkinson's disease criteria. All patients with a diagnosis of Parkinsonism without dementia are eligible. During this study, the patient will be asked to complete a scratch and sniff test, answer a few additional questions and allow a movement disorder fellow evaluate their medical record. For more information, please call (858) 822-MOVE or email email@example.com. Currently enrolling.