Research Studies: Corticobasal Degeneration & Progressive Supranuclear Palsy

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL,  Enrolling)

This research study is looking to learn more about cognition and/or movement problems in patietns with frontotemporal dementia

Patients who qualify are those who have been diagnosed with the following or have a blood relative who is diagnosed with the following:

  • Sematic variant Primary Progressive Aphasia (PPA)
  • Progressive Supranuclear Palsy (PSP)
  • Frontotemporal Dementia with Amyotrophic Lateral Sclerosis (FTD-ALS)
Participation includes an evaluation of cognition, a physical examination, questionnaires, and a sample of blood. Patients may also be asked for an MRI scan or cerebrospinal fluid. If FTLD runs in the patient's family, they may be asked to return in one year for a follow-up appointment where assessments will be repeated. For more research study please contact our research coordinator Kim Thomas Tel: 858-822-5751 or via email kkt008@ucsd.edu.

For more information on all participating sites, please follow this link: https://www.rarediseasesnetwork.org/ARTFL/index.htm

Atypical Parkinsonism: 

  • Corticobasal Degeneration

Four Repeat Tauopathy Neuroimaging Initiative (4RTNI)

This research study is studying the best method of analysis to track patients with Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD) over time. During this year long study, patients will be asked to come in for 3 study visits (at baseline, 6 month, and 12 months) to complete a neurological examination, study partner questionnaires, memory testing, MRI scane, and a PET scan. Patients with PSP or CBD between the ages of 45 - 90 with a reliable study partner are eligible. Estimated start date in Summer 2016. For more information on this study, please contact (858) 822-MOVE or email mdcresearch@ucsd.edu.

Validation of new MDS PD Diagnostic Criteria

This study is validating new Parkinson's disease criteria. All patients with a diagnosis of Parkinsonism without dementia are eligible. During this study, the patient will be asked to complete a scratch and sniff test, answer a few additional questions and allow a movement disorder fellow evaluate theri medical record. For more information, please call (858) 822-MOVE or email mdcresearch@ucsd.edu.

For more information on all participating sites, please follow this link: https://www.rarediseasesnetwork.org/ARTFL/index.htm

Currently enrolling

  • Progressive Supranuclear Palsy (PSP)

Assessing Falls in Parkinson's Disease and other Movement Disorders

This research study is looking to validate a wearable multi-modal system in patients with an increased risk of falling. This technology could allow physicians to monitor and understand what causes certain patients to fall. Participation will consist of one study visit and two at home sessions with the multi-modal monitoring system. Patients with movement disorders may qualify for this study if they are over 50 years of age and have a history of falls. Enrollment on hold.

Epidermal Electronic System (EES) Sticker Sensory Studies

Dr. Litvan is studying the applicable uses of a sticker sensor called epidermal electronic system (EES) sensor. There are three uses currently being studied:

This sub-study is studying if this sticker sensor can be used to find out more about processing in the brain. The sticker sensor will be placed on the forehead and be connected to a portable EEG to measure their brain waves while viewing visual stimulus on a computer screen and/or listening to auditory stimulus. Patients may be asked to take this system home and complete 15 minutes of testing a day for a week. Currently enrolling.

Prior studies have demonstrated a hyper-activation of a laryngeal muscle at rest in patients with PSP with needle-based EMG. This sub-study is studying if this EES sticker sensor and standard transcutaneous EMG electrodes can replicate this study in a non-invasive manner. During this study, the sticker sensor will be placed on the throat to record muscle activation while the subject is making different phonations. Currently enrolling.

For more information on this study, please contact (858) 822-MOVE or email mdcresearch@ucsd.edu.

Familial PSP Study

This research study is hoping to identify gene variation involved in PSP. Patients diagnosed with PSP and who have a living blood relative with a neurological or psychological disorder may be eligible for this study. For more information on this study, please contact (858) 822-MOVE or email mdcresearch@ucsd.edu.

Currently enrolling.

Phase I Multiple Dose BMS Antibody Treatment

In collaboration with Bristol-Myers Squibb, Dr. Litvan is recruiting for a clinical trial to evaluate whether multiple doses of an investigational drug called BMS-986168 given intravenously over a course of about 6 months is safe and well-tolerated in subjects with PSP. BMS-986168 is an immunotherapy (antibody) drug designed to bind to and remove the free eTau (extracellular tau), which is believed to build up to abnormally high levels in the brains of subjects with PSP. Patients with PSP between 50 - 85 years of age who are able to walk with minimal assistance, willing to undergo 3 lumbar punctures (LPs) and 3 MRI scans, and have an available study partner may be eligible for this study. This study has open label extension continuation (not placebo-controlled) study available for patients after completion of the initial study. For more information on this study, please contact (858) 822-MOVE or email mdcresearch@ucsd.edu.

Enrollment on hold

Postural Stability in PSP

Drs. Litvan and Nandipati are studying postural stability in patients with PSP using an iPAD application. Eligible patients should be between 40-90 years of age, able to stand comfortably for 5 minutes unaided, and have no memory problems. For more information, please call (858) 822-MOVE or email mdcresearch@ucsd.edu. Estimated start date May 2016.

Validation of new MDS PD Diagnostic Criteria

This study is validating new Parkinson's disease criteria. All patients with a diagnosis of Parkinsonism without dementia are eligible. During this study, the patient will be asked to complete a scratch and sniff test, answer a few additional questions and allow a movement disorder fellow evaluate their medical record. For more information, please call (858) 822-MOVE or email mdcresearch@ucsd.edu. Currently enrolling.