group photo 

Members of the Mark Tuszynski Lab.

Welcome to the Tuszynski Lab

Research Foci



    Human ES cells implanted into Rat with complete spinal cord transection. Human axons (green) stream from the lesion site (LEFT) into the caudal spinal cord

    Most Important Research Papers

    • Rosenzweig ES, Brock JH, Lu P, Kumamaru H, Salegio EA, Weber JL, Liang JJ, Moseanko R, Hawbecker S, Huie JR, Havton LA, Jout-Lomas YS, Ferguson AR, Beattie MS, Bresnahana JC, Tuszynski MH. Restorative effects of human neural stem cell grafts to the primate spinal cord. Nature Medicine, 2018 Feb 26. PMID 29480894.
    • Poplawski GHD, Lie R, Hunt M, Kumamaru H, Lu P, Schafer M, Woodruff G, Robinsons J, Canete P, Dulin J, Geoffrey CG, Menzel L, Zheng B, Coppola C, Tuszynski MH. Adult CNS myelin enhances axonal outgrowth from neural stem cells. Science Translational Medicine, 2018; in press.
    • Dulin JN, Adler AF, Kumamaru H, Lee-Kubli C, Poplawski G, Storbl H, Gibbs D, Kadoya K, Fawcett JW, Lu P, Tuszynski MH. Injured adult motor and sensory axons regenerate into appropriate organotypic domains of spinal cord neural progenitor grafts. Nature Comm, 2018; 9:84.
    • Lu P, Ceto S, Wang Y, Graham L, Wu D, Kumamaru H, Boehle E, Tuszynski MH. Prolonged human neural stem cell maturation supports late functional recovery after spinal cord injury. Journal of Clinical Investigation, 2017; 127:3287-3299.
    • Kadoya K, Paul Lu P, Nguyen K, Lee-Kubli C, Yao L, Poplawski G, Dulin J, Takashima Y, Biane J, Conner J, Zhang S-C, Tuszynski MH. Robust corticospinal regeneration enabled by spinal cord reconstitution with homologous neural grafts. Nature Medicine, 2016; 22:479-487.
    • Biane JS, Takashima Y, Conner J, Scanziani M, Tuszynski MH. Thalamocortical projections exhibit plasticity onto behaviorally-relevant neurons during adult motor learning. Neuron 2016; 89:1173-1179.
    • Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski MH, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature 2016; 534:115-118.
    • Wang L, Conner JM, Nagahara AH, Tuszynski MH. Rehabilitation drives enhancement of neuronal structure in functionally relevant neuronal subsets. Proc Nat Acad Sci, 2016; 113: 2750-2775.
    • Tuszynski MH, Yang JH, Barba D, U HS, Bakay R, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. Neuronal responses to nerve growth factor gene therapy in Alzheimer's disease. JAMA Neurology, 2015; 72:1139-1147.
    • Lu P, Woodruff G, Wang Y, Graham L, Hunt M, Wu D, Boehle E, Ahmad R, Poplawski G, Brock J, Goldstein LSB, Tuszynski MH. Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury. Neuron, 2014; 83:789-96.
    • Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury: Cell-intrinsic mechanisms overcome spinal inhibition. Cell 2012, 14;150:1264-73. PMC3445432.
    • Wang L, Conner JM, Rickert JL, Tuszynski MH. Structural plasticity within highly specific neuronal populations identifies a parcellation of motor learning. Proc Nat Acad Sci, 2011, 108:2545-2550. PMC3038698.
    • Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, Havton LA, Bresnahan JC, Edgerton VR, Tuszynski M. Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nature Neuroscience, 2010, 13:1505-1510.
    • Alto L, Havton LA, Conner JM, Hollis ER, Blesch A, Tuszynski MH. Chemotropic guidance facilitates axonal regeneration into brainstem targets and synapse formation after spinal cord injury. Nature Neuroscience, 2009, 12: 1106-1113. PMCID 2753201.
    • Nagahara A, Merrill DA, Coppola G, Tsukada S, Schroder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JC, Rockenstein E, Chao MV, Koo E, Geschwind D, Masliah, Chiba AA, Tuszynski MH. Neuroprotective effects of BDNF in rodent and primate models of Alzheimer's disease. Nature Medicine, 2009, 15:331-337. PMC2838375.
    • Tuszynski MH et al. A phase I clinical trial of nerve growth factor gene therapy for Alzheimer's disease. Nature Medicine, 2005, 11:551-5.
    Contact Us 

    Mark Tuszynski MD, PhD, 

    Professor of Neurosciences

    Director, UCSD Translational Neuroscience Institute

    UC San Diego
    La Jolla, California 92093-0626

    Coleman Bud Mathews,
    Executive Assistant
    (858) 534-8857
    Fax: (858) 534-5220