Alexander Kleschevnikov is trained in physics, chemistry, biology, and neurophysiology. He earned his PhD in chemistry in 1983 at the Institute of Inorganic Chemistry in Moscow, Russia, and in 1998 completed a doctor of biology degree in neurosciences at the Institute of Higher Nervous Activity, also in Moscow.
During his studies, he was employed as a research scientist at the Medical State Institute in Tashkent, Russia, from 1984 to 1987. In 1987 he advanced to senior research scientist at the Institute of Higher Nervous Activity and Neurophysiology in Moscow.
In 1989 he became head of a research group at the Brain Research Institute in Moscow. In the U.S., Dr. Kleschevnikov took a position as research associate at Northwestern University and in 2001 became a research associate in the Department of Neurology and Neurological Sciences at Stanford University.
Dr. Kleschevnikov is a founding member of the Down Syndrome Center for Research and Treatment at UCSD. His research focuses on synaptic plasticity, learning and memory in Down syndrome. In these studies he used several mouse genetic models of Down syndrome, such as Ts65Dn, Ts1Cje and Ts1Thr. A number of findings revealed cellular mechanisms underlying memory deficits in Down syndrome and may lead to development of specific treatment improving learning and memory in Down syndrome and related disorders.
Dr. Kleschevnikov plans to expand the research of molecular and cellular mechanisms underlying deficits of learning and memory in Down syndrome and related disorders. This will include studies of the pH regulatory system in Down syndrome. Preliminary data show that pH regulation is altered in the brain of Down syndrome subjects, and that this change may contribute to abnormal synaptic plasticity.
He also plans to examine the status of the inflammatory system in Down syndrome and interaction between the inflammatory system and long-term synaptic plasticity. He is also interested in studying the mechanisms by which beta-amyloid and related molecules affect synaptic plasticity in the animal models of Alzheimer’s disease.
Dr. Kleschevnikov has extensive experience as an electrophysiologist along with a strong physiological and pharmacological background in synaptic neurotransmissions particularly in the glutamate, acetylcholine and GABA receptors that play a major role in the neurodegenerative disorders. His publication in the Journal of Neuroscience was a major contribution to understanding the widely used Ts65Dn mouse model of Down syndrome. His additional research articles also have been published in top-rated journals.