Daniel Gibbs earned his BS in zoology and PhD in anatomy and physiology from the University of Dundee, Scotland. From 2000-2008 he was a postdoctoral scholar in cell biology, gene therapy and neuroscience at UC San Diego.
Dr. Gibbs has an extensive background in gene therapy for retinal degenerative disease, neurodegenerative disease and viral vector development. This includes a critical role in elucidating the retinal pathology associated with Usher Syndrome, leading to clinical trials of MYO7A gene replacement therapy for Usher 1B.
As an Assistant Professor with the Translational Neurosciences Institute, he is developing a research program targeting neural repair and neuroprotection in the injured and diseased retina, spinal cord and brain, using combinatorial gene and stem cell therapies. He is also developing viral vector tools for interrogating the structure, function and transcriptional state of the CNS across multiple scales, from sub-cellular to systems level analyses.
Kusne Y, Gibbs D, Ghosh S: Targeting aPKC simultaneously disables cell autonomous and non-cell autonomous oncogenic signaling in Glioblastoma: Science Signaling: Under review.
Reuter JD, Fang X, Ly CS, Gibbs D: Assessment of hazard risk associated with intravenous use of viral vectors in rodents. Journal of Comparative Medicine: 62(5): 361-370.
Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS: The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65. Human Molecular Genetics: 20(13): 2560-70.
Jacobson SG, Cideciyan AV, Gibbs D, Sumaroka A, Roman AJ, Aleman TS, Schwartz SB, Olivares MB, Russell RC, Steinberg JD, Kenna MA, Kimberling WJ, Rehm HL, Williams DS: Retinal disease course in Usher syndrome 1B due to MYO7A mutations. Investigative Ophthalmology and Visual Science: 52(11): 7924-36.
Gibbs D, Diemer T, Kahanobdee K, Hu J, Bok D, Williams DS: Function of MYO7A in the human RPE and the validity of the Shaker1 mice as a model for Usher syndrome 1B. Investigative Ophthalmology and Visual Science: 51(2): 1130-1135.
Schwander M, Lopez V, Sczaniecka A, Gibbs D, Lillo C, Delano D, Tarantino L, Wiltshire T, Williams DS, and Mueller U: A Novel Allele of Myosin VIIa Reveals a Critical Function for the C-terminal FERM Domain for Melanosome Transport in Retinal Pigment Epithelial Cells. Journal of Neuroscience: 29(50):15810-15818.
Gibbs D, Cideciyan AV, Jacobson SG and Williams DS: Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence. Investigative Ophthalmology and Visual Science: 50:4386-4393.