Ephron Rosenzweig 

Ephron Rosenzweig, PhD 

Assistant Adjunct Professor

 

Contact Information

Phone: (858) 822-5976
Email: erosenzweig@ucsd.edu
Fax: (858) 534-5220

Location
Biomed Research Facility-2
Room 2125
Mail Code 0626

Mailing Address
9500 Gilman Drive #0626
La Jolla, CA  92093-0626

Ephron Rosenzweig earned his BA in Integrative Biology from UC Berkeley and his PhD in Neuroscience from University of University of Arizona, Tucson, followed by postdoctoral posts at Washington University in St. Louis and UC San Diego, where he became an assistant project scientist in 2008.

He has extensive experience in CNS plasticity and regeneration research, in both rodent and primate models of spinal cord injury. In addition, he has many years of experience in electrophysiological research on learning, memory, and aging. Since 2005, he has directed the Primate Spinal Cord Injury Research Project at Dr. Mark Tuszynski’s Center for Neural Repair at UCSD. This collaborative effort is a comprehensive evaluation of potential treatments for spinal cord injury.

Dr. Rosenzweig primarily researches spinal cord injury repair. Much of his work is part of the California Primate Spinal Cord Injury Consortium, a group composed of researchers from UCSD, UCLA, UCSF, UC Irvine, UC Davis, Colorado State University, and the Swiss Federal Institute of Technology.

Drawing only the most promising candidate treatments from research in rodent models of SCI, this group examines the neuroanatomical, electrophysiological, and functional efficacies of those treatments in a non-human primate (NHP) model of SCI. His main current focus is on the formation of long-distance neuronal relays using neural stem cells transplanted into SCI lesions. As part of the UCSD Center for Neural Repair, he also collaborates on similar studies in rodents (Lu et al., Cell, 2012).

Recently, Dr. Rosenzweig expanded his research program to include central neuropathic pain, which not only affects many people with SCI, but can also result from multiple sclerosis and stroke. He is attempting to use DREADD technology (Designer Receptors Exclusively Activated by Designer Drugs) to specifically alleviate central neuropathic pain in rodent models.

Nielson, J.L., Guandique, C.F., Liu, A.W., Burke, D.A., Lash, A.T., Moseanko, R., Hawbecker, S., Strand, S.C., Zdunowski, S., Irvine, K.-A., Brock, J.H., Nout, Y.S., Gensel, J.C., Anderson, K.D., Segal, M.R., Rosenzweig, E.S., Magnuson, D.S.K., Whittemore, S.R., McTigue, D.M., Popovich, P.G., Rabchevsky, A.G., Scheff, S.W., Steward, O., Courtine, G., Edgerton, V.R., Tuszynski, M.H., Beattie, M.S., Bresnahan, J.C., & Ferguson, A.R. (2014). Development of a Database for Translational Spinal Cord Injury Research. J Neurotrauma, In press.

Lu, P., Wang, Y., Graham, L., McHale, K., Gao, M., Wu, D., Brock, J., Blesch, A., Rosenzweig, E.S., Havton, L.A., Zheng, B., Conner, J.M., and Tuszynski, M.H. (2012). Long-distance growth and connectivity of neural stem/progenitor cells after severe spinal cord injury. Cell, 150:1264-1273.

Nout, Y.S., Rosenzweig, E.S., Brock, J.H., Ferguson, A.R., Strand, S.C., Moseanko, R., Hawbecker, S., Zdunowski, S., Courtine, G., Nielson, J.L., Roy, R.R., Zhong, H., Edgerton, V.R., Beattie, M.S., Bresnahan, J.C., and Tuszynski, M.H. (2012). Animal models of neurologic disorders: a non-human primate model of spinal cord injury. Neurotherapeutics, 9:380-392.

Nout, Y.S., Ferguson, A.R., Strand, S.C., Moseanko, R., Hawbecker, S., Zdunowski, S., Nielson, J.L., Roy, R.R., Zhong, H., Rosenzweig, E.S., Brock, J.H., Edgerton, V.R., Tuszynski, M.H., Beattie, M.S., and Bresnahan, J.C. (2012). Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey. Neurorehab Neural Repair, 26:556-569.

Rosenzweig, E.S., Courtine, G., Jindrich, D.L., Brock, J.H., Strand, S.C., Ferguson, A.R., Nout, Y.S., Roy, R.R., Miller, D.M., Beattie, M.S., Havton, L.A., Bresnahan, J.C., Edgerton, V.R., and Tuszynski, M.H., Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nature Neuroscience, 2010. 13:1505-1510.

Brock, J.H., Rosenzweig, E.S., Blesch, A., Moseanko, R., Havton, L.A., Edgerton, V.R., and Tuszynski, M.H., Local and remote growth factor effects after primate spinal cord injury. Journal of Neuroscience, 2010. 30:9728-9737.

Becker, D., Gary, D.S., Rosenzweig, E.S., Grill, W.M., and McDonald, J.W., Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats. Exp Neurol, 2010. 222: p. 211-8.

Rosenzweig, E.S., Brock, J.H., Culbertson, M.D., Lu, P., Moseanko, R., Edgerton, V.R., Havton, L.A., and Tuszynski, M.H., Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys. J Comp Neurol, 2009. 513: p. 151-63.

Taylor, S.J., Rosenzweig, E.S., McDonald, J.W., 3rd, and Sakiyama-Elbert, S.E., Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injury. J Control Release, 2006. 113: p. 226-35.

Rosenzweig, E.S., Redish, A.D., McNaughton, B.L., and Barnes, C.A., Hippocampal map realignment and spatial learning. Nat Neurosci, 2003. 6: p. 609-15.

Rosenzweig, E.S. and Barnes, C.A., Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog Neurobiol, 2003. 69: p. 143-79.

Redish, A.D., Battaglia, F.P., Chawla, M.K., Ekstrom, A.D., Gerrard, J.L., Lipa, P., Rosenzweig, E.S., Worley, P.F., Guzowski, J.F., McNaughton, B.L., and Barnes, C.A., Independence of firing correlates of anatomically proximate hippocampal pyramidal cells. J Neurosci, 2001. 21: p. RC134.

Redish, A.D., Rosenzweig, E.S., Bohanick, J.D., McNaughton, B.L., and Barnes, C.A., Dynamics of hippocampal ensemble activity realignment: time versus space. J Neurosci, 2000. 20: p. 9298-309.

Rosenzweig, E.S., Rao, G., McNaughton, B.L., and Barnes, C.A., Role of temporal summation in age-related long-term potentiation-induction deficits. Hippocampus, 1997. 7: p. 549-58.