James Brewer 

James B. Brewer, MD, PhD 

Professor

 

Contact Information

ACTRI, Room 3W120

Email: jbrewer@ucsd.edu
Phone: 858-534-1237
Fax: 858-534-1240

Mailing Address:
9500 Gilman Drive # 0949
La Jolla, CA 92093-0949


Dr. Brewer received his graduate and medical training at Stanford University and his neurology residency training at Johns Hopkins University. He joined the Department of Neurosciences in 2004, in a joint recruitment of the Departments of Neurosciences and Radiology, and is a leading investigator at the interdisciplinary Multimodal Imaging Laboratory.

Dr. Brewer's primary research interest is human memory. He uses functional and structural magnetic resonance imaging (MRI) to study memory processes in volunteers with healthy memory and in patients with memory impairment, such as cases caused by Alzheimer's disease (AD).

This research focuses on the medial temporal lobe (MTL) of the brain, which shows selective damage early in the course of AD. The overarching aim of the work is to better understand the memory function of distinct MTL substructures and the nature of the interaction between those substructures and other brain regions.

Dr. Brewer was one of the first researchers to show that functional MRI (fMRI) can identify distinct activations within the MTL. He and colleagues were the first to use the technique of event-related fMRI to identify brain activity that is directly related to the process of forming memories.

In addition, Dr. Brewer teaches neurosciences and neurology to graduate students, medical students, and residents. He participates as a lecturer in courses on fMRI and memory, assists in neuroanatomy instruction for medical students, and is an active participant in the Neurosciences Graduate Program. He is Co-Director of the UCSD Neurology Residents' Clinic at the VA San Diego Healthcare System, where he advises and mentors neurology residents in clinical neurology.

He is an attending physician at the UCSD and VA Medical Centers. In addition to his university service, Dr. Brewer is an ad hoc reviewer for several journals, including Neurology, Trends in Neurosciences, and Hippocampus.

Multimodal Imaging Laboratory

See a video discussion on neuroimaging and Alzheimer's disease

Dr. Brewer’s primary research interest is human memory. He uses functional and structural magnetic resonance imaging (MRI) to study memory processes in volunteers with healthy memory and in patients with memory impairment, such as caused by Alzheimer’s disease (AD).

This research focuses on the medial temporal lobe (MTL) of the brain, which shows selective damage early in the course of AD. The overarching aim of the work is to better understand the memory function of distinct MTL substructures and the nature of the interaction between those substructures and other brain regions.

Dr. Brewer was one of the first researchers to show that functional MRI (fMRI) can identify distinct activations within the MTL. He and colleagues were the first to use the technique of event-related fMRI to identify brain activity that is directly related to the process of forming memories.

Search-Related Suppression of Hippocampus and Default Network Activity during Associative Memory Retrieval.
Reas ET,Gimbel SI,Hales JB,Brewer JB.
Publish Date :2011
PMID :22046159

Amyloid-β associated volume loss occurs only in the presence of phospho-tau.
Desikan RS,McEvoy LK,Thompson WK,Holland D,Roddey JC,Blennow K,Aisen PS,Brewer JB,Hyman BT,Dale AM,Alzheimer’s Disease Neuroimaging Initiative.
Publish Date :2011 Oct
PMID :22002658

Predicting MCI outcome with clinically available MRI and CSF biomarkers.
Heister D,Brewer JB,Magda S,Blennow K,McEvoy LK,Alzheimer's Disease Neuroimaging Initiative.
Publish Date :2011 Oct 25
PMID :21998317

Stability of resting fMRI interregional correlations analyzed in subject-native space: A one-year longitudinal study in healthy adults and premanifest Huntington's disease.
Seibert TM,Majid DS,Aron AR,Corey-Bloom J,Brewer JB.
Publish Date :2012 Feb 1
PMID :21945695

CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent manner.
Murphy EA,Roddey JC,McEvoy LK,Holland D,Hagler DJ Jr,Dale AM,Brewer JB,Alzheimer’s Disease Neuroimaging Initiative.
Publish Date :2011 Sep 3
PMID :21892657

Default network correlations analyzed on native surfaces.
Seibert TM,Brewer JB.
Publish Date :2011 Jun 15
PMID :21514321

Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis.
McEvoy LK,Holland D,Hagler DJ Jr,Fennema-Notestine C,Brewer JB,Dale AM,Alzheimer's Disease Neuroimaging Initiative.
Publish Date :2011 Jun
PMID :21471273

Reaction time, memory strength, and fMRI activity during memory retrieval: Hippocampus and default network are differentially responsive during recollection and familiarity judgments.
Gimbel SI,Brewer JB.
Publish Date :2011 Mar
PMID :21278912

The timing of associative memory formation: frontal lobe and anterior medial temporal lobe activity at associative binding predicts memory.
Hales JB,Brewer JB.
Publish Date :2011 Apr
PMID :21248058

Functional brain imaging in the clinical assessment of consciousness.
Rafii MS,Brewer JB.
Publish Date :2010 Nov 30
PMID :21151340

Parietal activity in episodic retrieval measured by fMRI and MEG.
Seibert TM,Gimbel SI,Hagler DJ Jr,Brewer JB.
Publish Date :2011 Mar 15
PMID :21134473

Quantitative structural MRI for early detection of Alzheimer's disease.
McEvoy LK,Brewer JB.
Publish Date :2010 Nov
PMID :20977326

Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease.
Karow DS,McEvoy LK,Fennema-Notestine C,Hagler DJ Jr,Jennings RG,Brewer JB,Hoh CK,Dale AM,Alzheimer's Disease Neuroimaging Initiative.
Publish Date :2010 Sep
PMID :20720076

Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease.
McEvoy LK,Edland SD,Holland D,Hagler DJ Jr,Roddey JC,Fennema-Notestine C,Salmon DP,Koyama AK,Aisen PS,Brewer JB,Dale AM,Alzheimerʼs Disease Neuroimaging Initiative.
Publish Date :2010 Jul-Sep
PMID :20683184

Activity in the hippocampus and neocortical working memory regions predicts successful associative memory for temporally discontiguous events.
Hales JB,Brewer JB.
Publish Date :2010 Sep
PMID :20667491

Six-month atrophy in MTL structures is associated with subsequent memory decline in elderly controls.
Murphy EA,Holland D,Donohue M,McEvoy LK,Hagler DJ Jr,Dale AM,Brewer JB,Alzheimer's Disease Neuroimaging Initiative.
Publish Date :2010 Dec
PMID :20633660

Early parietal response in episodic retrieval revealed with MEG.
Seibert TM,Hagler DJ Jr,Brewer JB.
Publish Date :2011 Feb
PMID :20623759

CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease.
Fjell AM,Walhovd KB,Fennema-Notestine C,McEvoy LK,Hagler DJ,Holland D,Brewer JB,Dale AM,Alzheimer's Disease Neuroimaging Initiative.
Publish Date :2010 Feb 10
PMID :20147537

Early stages of figure-ground segregation during perception of the face-vase.
Pitts MA,Martínez A,Brewer JB,Hillyard SA.
Publish Date :2011 Apr
PMID :20146604

Brain atrophy in healthy aging is related to CSF levels of Aβ1-42.
Fjell AM,Walhovd KB,Fennema-Notestine C,McEvoy LK,Hagler DJ,Holland D,Blennow K,Brewer JB,Dale AM,Alzheimer's Disease Neuroimaging Initiative.
Publish Date :2010 Sep
PMID :20051356
 
1993-2000 Medical Scientist Training Program Grant
  National Institute of Health
1992-1993 Fulbright Scholarship