Dr. Iragui has established a thriving clinical practice as well as a strong referral base in general adult neurology, with a subspecialty in epilepsy and neurophysiology, including evoked potentials. He is Director of the Clinical Neurophysiology laboratories at the UCSD and VA San Diego Medical Centers, where he interprets the majority of the EEGs and evoked potentials, and Director of the UCSD Epilepsy Center at the Perlman Ambulatory Care Center and Jacobs Medical Center in La Jolla.
In the research areas of evoked potentials and epilepsy, Dr. Iragui is collaborating with Dr. John Olichney in a series of projects on the electrophysiological correlates of human memory function. These studies utilize an incidental learning paradigm during a simple semantic categorization task. He also continues to collaborate with Dr. Marta Kutas on event-related potentials (ERPs) in aging, dementia, Alzheimer's disease (AD), and Parkinson's disease.
Their studies examine the effects of normal aging in ERPs during a semantic categorization task. Results suggest that non-demented parkinsonian patients have larger N400 amplitudes than normal controls, whereas demented parkinsonian patients resemble patients with AD. These findings have important implications for understanding the role of the basal ganglia in semantic priming, in line with convergent evidence derived from studies with functional MRI.
Dr. Iragui's other research activities focus on clinical epilepsy, in particular, the patterns of ictal onset and spread of seizures recorded from foramen ovale electrodes. This technique reliably localizes the site of seizure onset in mesial temporal lobe epilepsy and obviates the need for more invasive intracranial recordings with subdural or depth electrodes. UCSD Epilepsy Center researchers have substantial experience in foramen ovale recordings, a technique that has not yet achieved widespread use in the United States.
Dr. Iragui also uses his clinics as teaching opportunities. He provides group and individual instruction for graduate and medical students, residents, and postdoctoral fellows. In the spring of each year he teaches Basic Medical Neurology and Principles of Pharmacology, both of which are core medical school courses. He offers Journal Club and epilepsy case conferences every quarter. Dr. Iragui is an active member of several major professional societies, including the American Academy of Neurology, American Epilepsy Society, and American EEG Society.
He has also served as a grant reviewer for UC Discovery Grants, the Center for Medical Cannabis Research, and the Biomedical Research Council of Singapore. He earlier served on the Editorial Board of Neurologia. Dr. Iragui's public service at the local level includes membership on the Professional Advisory Board of the Epilepsy Society of San Diego County. He also serves as Vice President of the Society's Board of Directors.