Welcome to Desplats Laboratory
During the last years, the exponential grow of Neuroepigenetics demonstrated the involvement of DNA methylation and histone modifications on the pathology of a variety of neurological diseases and, importantly, proved their relevance in post-mitotic cells in the human brain. The work of our lab reporting mislocalization of DNA methyltransferase 1 in the brains of Parkinson’s disease (PD) patients was among a few pioneer studies focused on epigenetic mechanisms disrupted in neurodegeneration (Desplats et al 2008 JBC).
Research in our lab is aimed at elucidating the dynamic mechanisms of DNA methylation, which might contribute to onset and progression of the most prevalent neurodegenerative diseases of the elderly, Parkinson’s and Alzheimer’s. At the center of our work is a strong interest in translational neuroscience, therefore we combine aspects of cellular physiology and molecular neuroscience, integrating the analysis of human postmortem brain samples, transgenic animals and cellular models to address mechanistic questions, while identifying therapeutic targets and providing novel diagnostic tools.