LATE-Discovery and Trial Ready Cohort for Limbic Predominant Age Related TDP-43 Encephalopathy (TRC LATE)

Discovery and Trial Ready Cohort for Limbic Predominant Age Related TDP-43 Encephalopathy (TRC LATE)

Study Description

The goal of this multicenter research study is to better understand Limbic Predominant Age Related TDP-43 Encephalopathy (LATE). Clinically, LATE resembles Alzheimer’s Disease (AD) in that it causes a progressive amnestic syndrome; however, its pathophysiology is distinct and poorly understood. 

Our aims are to:

1. Define and validate novel biomarkers that would aid in the early detection and diagnosis of LATE
2. Track and differentiate disease progression of LATE from AD
3. Learn about the attitudes and inclination of individuals to participate in clinical trials for LATE. 

We plan to evaluate participants enrolled in the UCSD Shiley-Marcos ADRC Cognitive Aging Longitudinal Study with additional imaging and assessment procedures. By doing this, we hope to validate and further refine the clinical criteria of LATE by assessing the diagnostic utility of neuroimaging and neuropsychological biomarkers in this condition.

PIs

Douglas Galasko, MD and Diane Jacobs, PhD

Required Diagnosis

Mild cognitive impairment (MCI) with amnestic predominant syndrome

 OR 

Mild dementia with amnestic predominant syndrome 

OR 

Unimpaired cognition with subjective memory complaint 

OR 

Unimpaired cognition with hippocampal atrophy on existing MRI

Age

85+ 

OR 

75+ if memory impaired and amyloid negative (based on existing PET/fluid biomarkers)

Length

Annual lifelong

Lumbar Puncture

Optional

MRI

Required (Annually)

Amyloid PET

Optional

Tau PET

Optional

Other Procedures

FDG PET (Every 2 years) 

Blood Draw (Annually) 

Smartphone-based Assessments (Every 6 months on own or study-provided device) 

Cognitive Testing/Questionnaires (Annually)

Compensation

$50 per blood draw

$50 per MRI scan

$50 per FDG PET scan

$50 for completion of questionnaires

$50 for completion of in-depth interview

$50 for smartphone-based assessments

Link to Brain Blast Video

N/A

Link to Study Flyer/Additional Materials

Study flyer coming soon!

To learn more about LATE, read this article.

Contact

Alexandra Mendoza, alm021@health.ucsd.edu