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Department of Neurosciences Department of Neurosciences
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Publications

Selected Publications

2023

  • Kim HJ, Saikia JM, Monte KMA, Ha E, Romaus-Sanjurjo D, Sanchez JJ, Moore AX, Hernaiz-Llorens M, Chavez-Martinez CL, Agba CK, Li H, Zhang J, Lusk DT, Cervantes KM, Zheng B. Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration. Neuron, 2023, https://doi.org/10.1016/j.neuron.2023.09.019
  • Zheng B, Tuszynski MH. Regulation of axonal regeneration after mammalian spinal cord injury. Nat Rev Mol Cell Biol. 2023 Jun;24(6):396-413.

2022

  • Geoffroy CG, Meves JM, Kim HJM, Romaus-Sanjurjo D, Sutherland TC, Li JJ, Suen J, Sanchez JJ, Zheng B. Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting. iScience. 2022 Oct 17;25(11):105383.
  • Romaus-Sanjurjo D, Saikia JM, Kim HJ, Tsai KM, Le GQ, Zheng B. Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury. Cell Death Discov. 2022 Sep 20;8(1):390.
  • Saikia JM, Chavez-Martinez CL, Kim ND, Allibhoy S, Kim HJ, Simonyan L, Smadi S, Tsai KM, Romaus-Sanjurjo D, Jin Y, Zheng B. A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord. J Neurosci. 2022 May 4;42(18):3716-3732.

2021

  • Escartin C et al., Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 Mar;24(3):312-325. 
  • Li Y, Ritchie EM, Steinke CL, Qi C, Chen L, Zheng B, Jin Y. Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. Elife. 2021 Jan 21;10:e63509.

2020

  • Poplawski GHD, Kawaguchi R, Van Niekerk E, Lu P, Mehta N, Canete P, Lie R, Dragatsis I, Meves JM, Zheng B, Coppola G, Tuszynski MH. Injured adult neurons regress to an embryonic transcriptional growth state. Nature. 2020 May;581(7806):77-82.

2019 

  • Jin Y, Zheng B. Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management. Annu Rev Cell Dev Biol. 2019 Oct 6;35:501-521.
  • Zheng B, Lorenzana AO, Ma L. Understanding the axonal response to injury by in vivo imaging in the mouse spinal cord: A tale of two branches. Exp Neurol. 2019 Aug;318:277-285.

2018

  • Chen M, Geoffroy CG, Meves JM, Narang A, Li Y, Nguyen MT, Khai VS, Kong X, Steinke CL, Carolino KI, Elzière L, Goldberg MP, Jin Y, Zheng B. Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Cell Rep. 2018 Mar 27;22(13):3587-3597.
  • Narang A, Zheng B. To Scar or Not to Scar. Trends Mol Med. 2018;24(6):522-524.
  • Meves JM, Geoffroy CG, Kim ND, Kim JJ, Zheng B. Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury. Exp Neurol. 2018;309:32-43.
  • Poplawski GHD, Lie R, Hunt M, Kumamaru H, Kawaguchi R, Lu P, Schäfer MKE, Woodruff G, Robinson J, Canete P, Dulin JN, Geoffroy CG, Menzel L, Zheng B, Coppola G, Tuszynski MH.Adult rat myelin enhances axonal outgrowth from neural stem cells. Sci Transl Med. 2018 May 23;10(442):eaal2563.

2017

  • Geoffroy CG, Meves JM, Zheng B. (2017). The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms. Neurosci. Lett. pii: S0304-3940(16)30842-4. 
  • Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B. In Vivo Imaging of CNS Injury and Disease. J Neurosci. 2017 Nov 8;37(45):10808-10816.

2016

  • Meves JM, Zheng B. (2016). Synaptic Suppression of Axon Regeneration. Neuron 92, 267-269.
  • Chen M, Geoffroy CG, Wong HN, Tress O, Nguyen MT, Holzman LB, Jin Y, Zheng B. (2016). Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Sci. Rep. 6, 31482.
  • Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B. (2016). Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System. Cell Rep. 2016 Apr 12;15(2):238-46.

2015

  • Lorenzana, A. O., Lee, J. K., Mui, M., Chang, A., & Zheng, B. (2015). A surviving intact branch stabilizes remaining axon architecture after injury as revealed by in vivo imaging in the mouse spinal cord. Neuron 86, 947-54.
  • Geoffroy, C. G., Lorenzana, A. O., Kwan, J. P., Lin, K., Ghassemi, O., Ma, A., Xu, N., Creger, D., Liu, K., He, Z., and Zheng, B. (2015). Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice. J. Neurosci. 35, 6413-28.

2014

  • Chen, M., and Zheng, B. (2014). Axon plasticity in the mammalian central nervous system after injury. Trends Neurosci. 37, 583-93.
  • Meves J. M. and Zheng, B. (2014). Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury. Neural Regen. Res. 9, 460-1.
  • Lemmon et al. (2014). Minimum Information About a Spinal Cord Injury Experiment (MIASCI) - a proposed reporting standard for spinal cord injury experiments. J. Neurotrauma 31, 1354-61.
  • Geoffroy, C. G. and Zheng, B. (2014). Myelin-associated inhibitors in axonal growth after CNS injury. Curr. Opin. Neurobiol. 27, 31-8.
  • Zheng, B. and Fouad, K. (2014). Myelin-associated axon growth inhibitors. In Textbook of Neural Repair & Rehabilitation, Volume I - Neural Repair and Plasticity. M. Selzer, S. Clarke, L. Cohen, G. Kwakkel, and R. Miller, eds. pp. 339-48. Cambridge University Press.

2012

  • Lu, P., Wang, Y., Graham, L., McHale, K., Gao, M., Wu, D., Brock, J., Blesch, A., Rosenzweig, E. S., Havton, L. A., Zheng, B., Conner, J. M., Marsala, M., Tuszynski, M. H. (2012). Long-distance growth and connectivity of neural stem cells after severe spinal cord injury: Cell-intrinsic mechanisms overcome spinal inhibition. Cell 150, 1264-73.
  • Dudanova, I., Kao, T. J., Herrmann, J. E., Zheng, B., Kania, A., Klein, R. (2012). Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance. J. Neurosci. 32, 5209-15.
  • Dickendesher, T. L., Baldwin, K. T., Mironova, Y. A., Koriyama, Y., Raiker, S. J., Askew, K. L., Wood, A., Geoffroy, C. G., Zheng, B., Liepmann, C. D., Katagiri, Y., Benowitz, L. I., Geller, H. M., Giger, R. J. (2012). NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat. Neurosci. 15, 703-12.

2011

  • Chong, S. Y., Rosenberg, S. S., Fancy, S. P., Zhao, C., Shen, Y. A., Hahn, A. T., McGee, A. W., Xu, X., Zheng, B., Zhang, L. I., Rowitch, D. H., Franklin, R. J., Lu, Q. R., Chan, J. R. (2011). Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc. Natl. Acad. Sci. USA. 109, 1299-304.
  • Ruby, K. M. and Zheng, B. (2011). Genetic engineering of human embryonic stem cells: focusing on targeted modification. In Stem Cell Bioengineering and Tissue Engineering Microenvironment. S. Prakash and D. Shum-Tim, eds. pp. 231-51. World Scientific Publishing Company.
  • Wang, L., Klein, R., Zheng, B., Marquardt, T. (2011). Anatomical Coupling of Sensory and Motor Nerve Trajectory via Axon Tracking. Neuron 71, 263-77.
  • Lee, J. K, and Zheng, B. (2011). Role of myelin-associated inhibitors in axonal repair after spinal cord injury. Exp Neurol. 235, 33-42.

2010

  • Lee, J. K., Chow, R., Xie, F., Chow, S. Y., Tolentino, K. E., and Zheng, B. (2010). Combined genetic attenuation of myelin and Semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regeneration. J. Neurosci. 30, 10899-10904.
  • Liu, K., Lu, Y., Lee, J. K., Samara, R., Willenberg, R., Sears-Kraxberger, I., Tedeschi, A., Park, K. K., Jin, D., Cai, B., Xu, B., Connolly, L., Steward, O., Zheng, B., and He, Z. (2010). PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat. Neurosci. 13, 1075-1081.
  • Lee, J. K., Geoffroy, C. G., Chan, A. F., Tolentino, K. E., Crawford, M. J., Leal, M. A., Kang, B., and Zheng, B. (2010). Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron 66, 663-670.
  • Hollis, E. R. 2nd, Jamshidi, P., Lorenzana, A. O., Lee, J. K., Gray, S. J., Samulski, R. J., Zheng, B., Tuszynski, M. H. (2010). Transient demyelination increases the efficiency of retrograde AAV transduction. Mol. Ther. 18, 1496-1500.
  • Masliah, E., Xie, F., Dayan, S., Rockenstein, E., Mante, M., Adame, A., Patrick, C. M., Chan, A. F., Zheng, B. (2010). Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice. Neuroscience 169, 488-494.
  • Herrmann, J. E., Shah, R. R., Chan, A. F., and Zheng, B. (2010). EphA4 deficient mice maintain astroglial-fibrotic scar formation after spinal cord injury. Exp. Neurol. 223, 582-598.
  • Herrmann, J. E., Pence, M. A., Shapera, E. A., Shah, R. R., Geoffroy, C. G., and Zheng, B. (2010). Generation of an EphA4 conditional allele in mice. Genesis 48, 101-105.
  • Gil, V., Bichler, Z., Lee, J. K., Seira, O., Llorens, F., Bribian, A., Morales, R., Claverol-Tinture, E., Soriano, E., Sumoy, L., Zheng, B., Del Río, J. A. (2010). Developmental Expression of the Oligodendrocyte Myelin Glycoprotein in the Mouse Telencephalon. Cereb Cortex 20, 1769-1779.

2009

  • Lee, J. K.*, Case, L. C.*, Chan, A. F., Zhu, Y., Tessier-Lavigne, M., and Zheng, B. (2009). Generation of an OMgp allelic series in mice. Genesis 47, 751-6. *Equal contributors.
  • Lee, J. K, Chan, A. F., Luu, S. M., Zhu, Y, Ho, C., Tessier-Lavigne, M., and Zheng, B. (2009). Reassessment of corticospinal tract regeneration in Nogo deficient mice. J. Neurosci. 29, 8649-54.
  • Ruby, K. M, and Zheng, B. (2009). Gene targeting in a HUES line of human embryonic stem cells via electroporation. Stem Cells 27, 1496-506.

2008

  • Steward, O., Zheng, B., Tessier-Lavigne, M., Hofstadter, M., Sharp, K., Yee, K.M. (2008). Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice. J. Neurosci. 28, 6836-47.
  • Lee, J. K., and Zheng, B. (2008). Axon regeneration aft er spinal cord injury: insight from genetically modified mouse models. Rest. Neurol. Neurosci. 26, 175-82.
  • Davalos, D.*, Lee, J. K.*, Smith, W. B., Brinkman, B., Ellisman, M. H., Zheng, B., and Akassoglou, K. (2008). Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods 169, 1-7. * Equal contributors.
  • Xie, F., and Zheng, B. (2008). White matter inhibitors in CNS axon regeneration failure. Exp. Neurol. 209, 302-12.

2007

  • Schachtrup, C., Lu, P., Jones, L. L., Lee, J. K., Lu, J., Sachs, B. D., Zheng, B. and Akassoglou, K. (2007). Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor. Proc. Natl. Acad. Sci. USA. 104, 11814-9.
  • Steward, O., Zheng, B., Banos, K., and Yee, K. M. (2007). Response to: Kim et al., "Axon Regeneration in Young Adult Mice Lacking Nogo-A/B." Neuron 38, 187-199. Neuron 54, 191-5.
  • Mingorance-Le Meur, A., Zheng, B., Soriano, E., and Del Rio, J. A. (2007). Involvement of the Myelin-Associated Inhibitor Nogo-A in Early Cortical Development and Neuronal Maturation. Cereb. Cortex 17, 2375-86.
  • Yaron, A, and Zheng, B. (2007). Navigating their way to the clinic: emerging roles for axon guidance molecules in neurological disorders and injury. Dev. Neurobiol. 67, 1216-31.

2006

  • Zheng, B., Lee, J. K., and Xie, F. (2006). Genetic mouse models for studying inhibitors of spinal axon regeneration. Trends in Neurosci. 29, 640-6.

2005

  • Anderson, D. K, Beattie, M., Blesch, A., Bresnahan, J., Bunge, M., Dietrich, D., Dietz, V., Dobkin, B., Fawcett, J., Fehlings, M., Fischer, I., Grossman, R., Guest, J., Hagg, T., Hall, E. D., Houle, J., Kleitman, N., McDonald, J., Murray, M., Privat, A., Reier, P., Steeves, J., Steward, O., Tetzlaff, W., Tuszynski, M. H., Waxman, S. G., Whittemore, S., Wolpaw, J., Young, W., Zheng, B. (2005). Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord 43, 453-8.

Binhai's Publications 2003 - 2005 (selected)

  • Zheng, B.*, Atwal, J.*, Ho, C., Case, L., He, X. L., Garcia, K. C., Steward, O., and Tessier-Lavigne, M. (2005). Genetic deletion of Nogo Receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc. Natl. Acad. Sci. USA. 102, 1205-10. * Equal contributors.
  • Fontoura, P., Ho, P. P., DeVoss, J., Zheng, B., Lee, B. J., Kidd, B. A., Garren, H., Sobel, R. A., Robinson, W. H., Tessier-Lavigne, M., Steinman, L. (2004). Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J. Immunol. 173, 6981-92.
  • Steward, O., Zheng, B., Ho, C., Anderson, K., and Tessier-Lavigne, M. (2004). The dorsolateral corticospinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions. J. Comp. Neurol. 472, 463-77.
  • Karnezis, T., Mandemakers, W., McQualter, J. L., Zheng, B., Ho., P. P., Jordan, K. A., Murray, B. M., Barres, B., Tessier-Lavigne, M., Bernard, C. C. (2004). The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat. Neurosci. 7, 736-44.
  • Zheng, B., Ho, C., Li, S., Keirstead, H., Steward, O., and Tessier-Lavigne, M. (2003). Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 38, 213-24.
  • Steward, O., Zheng, B., and Tessier-Lavigne, M. (2003). False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J. Comp. Neurol. 459, 1-8.

Binhai's Publications prior to 2003 (selected)

  • Zheng, B., Vogel, H., Donehower, L. A., and Bradley, A. (2002). Visual genotyping of a coat color tagged p53 mutant mouse line. Cancer Biol. Ther. 1, 433-5.
  • Cleary, M. A., van Raamsdonk, C. D., Levorse, J., Zheng, B., Bradley, A., and Tilghman, S. M. (2001). Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice. Nat. Genet. 29, 78-82.
  • Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., and Lee, C. C. (2001). Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105, 683-94.
  • Zheng, B., Mills, A. A., and Bradley, A. (2001). Introducing defined chromosomal rearrangements into the mouse genome. Methods 24, 81-94.
  • Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der Horst, G. T., Hastings, M. H., and Reppert, S. M. (2000). Interacting molecular loops in the mammalian circadian clock. Science 288, 1013-9.
  • Zheng, B., Sage, M., Sheppeard, E. A., Jurecic, V., and Bradley, A. (2000). Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications. Mol. Cell. Biol. 20, 648-55.
  • Zheng, B., Sage, M., Cai, W. W., Thompson, D. M., Tavsanli, B. C., Cheah, Y. C., and Bradley, A. (1999). Engineering a mouse balancer chromosome. Nat. Genet. 22, 375-8.
  • Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., and Bradley, A. (1999). The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400, 169-73.
  • Zheng, B., Mills, A. A., and Bradley, A. (1999). A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Res. 27, 2354-60.
  • Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R., and Bradley, A. (1999). p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398, 708-13.
  • Prolla, T. A., Baker, S. M., Harris, A. C., Tsao, J. L., Yao, X., Bronner, C. E., Zheng, B., Gordon, M., Reneker, J., Arnheim, N., Shibata, D., Bradley, A., and Liskay, R. M. (1998). Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat. Genet. 18, 276-9.