iPSC-Induced Pluripotent Stem Cells to Study Human Models of Aging and Disease
| Study Name | iPSC-Induced Pluripotent Stem Cells to Study Human Models of Aging and Disease |
| Study Summary |
Participants are asked to provide skin cells from their forearm or the back of their tricep for the purpose of generating human pluripotent stem cells. These stem cells will be used to generate human brain cells (neurons) in the laboratory that have the same genetic makeup. None of the skin cells provided will be used to produce a human pregnancy or a cloned human person. We hope to create a ‘laboratory model’ using all of the genes from donors; they may help us study the causes of various diseases and test new medications and therapies. As part of this study, we will also be determining genetic makeup by analyzing DNA (DNA is the genetic material inside of your cells). Participants who agree to brain donation at the end of life will also be given the opportunity to provide a final skin sample for iPSC research at that time. |
| Principal Investigator(s) | Douglas Galasko, MD |
| Required Diagnosis | SMADRC longitudinal study ENROLLED participants with a diagnosis of Normal Cognition, Mild Cognitive Impairment (MCI), Alzheimer's disease (AD). or Down Syndrome (DS) |
| Age | 65 or older for Normal Controls; N/A for persons with diagnosis |
| Length | one time appointment for each sample collection agreed to |
| Lumbar Puncture | No |
| MRI | No |
| Amyloid PET | No |
| Tau PET | No |
| Compensation | No |
| Contact | |
| More Information |
Video about the Skin Biopsy Procedure Video about iPSC Research |
| Aftercare Instructions |