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Participate in a Huntington's Disease Clinical Trial or Study
Clinical Trial Information
Clinical trial and study information is updated periodically. Trials listed on this page may be closed. To confirm clinical trial or study availability, contact:
Jody Corey-Bloom, M.D., Ph.D.
Phone: 858-249-0568
Email: jcoreybloom@ucsd.edu
More Information
Search for UC San Diego Health Clinical TrialLearn More About UC San Diego Health Clinical Trials
Clinical Trials
Enrolling Now
New Studies Coming Soon
Check back here soon for more information about upcoming clinical trials we'll be enrolling for in the near future!
Experimental Studies
Enrolling Now
Delis Kaplan Executive Functioning System
ENROLLING NOW: The DKEFs (Delis-Kaplan Executive Function System) study is seeking participants to test a novel, iPad-based cognitive assessment specifically designed to detect subtle changes in thinking patterns associated with HD.
This is your chance to be among the first to experience this dynamic new assessment. The DKEFs is a comprehensive cognitive test battery that takes approximately 90 minutes to complete. As a participant, you'll receive $75 in compensation for your time and contribution.
We have exclusive access to this iPad-based DKEFs battery until the end of the summer, so don't miss this unique opportunity! Learn more about the DKEFs study and see if you qualify to participate in this groundbreaking research today!
Canary Speech Assessment
ENROLLING NOW: The Canary Speech Assessment is a brief, 10-minute test that analyzes your speech patterns to gain valuable insights into HD progression. This innovative research tool uses your voice to potentially identify a new biomarker for the disease.
By participating in this study you'll be helping researchers understand how speech can offer valuable clues about motor function. This could lead to earlier detection, better monitoring, and ultimately, improved care for people living with HD.
Are you interested in making a difference? Learn more about the Canary Speech Assessment and see if you qualify to join this groundbreaking research study by calling or emailing!
UCSD HD – Behavioral Questionnaire
ENROLLING NOW: A single-center observational study designed to assess behavioral changes characteristic of HD, including apathy, depression, irritability, anxiety, disinhibition, difficulty prioritizing and initiating activities. The HD-BQ consists of 30 items with a 3-point rating scale and takes about 5 minutes to complete. The study will be conducted at UCSD.
Plasma and Salivary Biomarkers for HD
ENROLLING NOW: A single-center observational study designed to assess the potential for saliva and plasma to serve as biospecimens for accessible biomarkers in Huntington’s disease. Upon visit, 4 mL of saliva and 2 tsp of blood will be collected and analyzed for huntingtin protein and various biomarkers. Such biomarkers may serve as a utility for symptom onset and, perhaps disease severity. The study will be conducted at UCSD.
Estimating HD Onset Using a Low-Cost Balance Assessment
ENROLLING NOW: A single-center, observational study designed to enhance the estimate of Huntington’s disease onset using a simple and practical body sway assessment device (i.e. BTrackS™). A brief balance assessment will be administered with and without a Paced Auditory Serial Addition Test (PASAT) to subjects with HD, at-risk for HD, and non-HD control subjects. The study will be conducted at UCSD.
Handwriting Movement Abnormalities as an Early Biomarker of Transition to Manifest HD
ENROLLING NOW: A single-center, observational study designed to test whether handwriting movement abnormalities can distinguish individuals at risk for developing HD from normal controls. The MovAlyzeR® software is used to run a brief battery of tasks consisting of five different writing patterns: simple loops, complex loops, rapid overlay circles, Archimedes’ spiral, and the sentence “The sky is blue”. The study will be conducted at UCSD.
Reaction Time in HD Using the Computer Test of Information Processing
ENROLLING NOW: A single-center, observational study designed to identify reaction time deficits that may be associated with individuals diagnosed with HD. A computerized reaction time task will be administered to subjects with diagnosed with HD, at-risk for HD, and non-HD control subjects. The study will be conducted at UCSD.
Observational Trials
Enrolling Now
Enroll-HD
Enroll-HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
ENROLLING NOW: A longitudinal, observational, multinational study that will integrate two existing Huntington's Disease (HD) registries, REGISTRY in Europe and COHORT in North America and Australia, while also expanding to include sites in Latin America and Asia. With no end date and annual assessments, the goal of Enroll-HD is to build a large and rich database of longitudinal clinical information and biospecimens. This database will serve as a basis for future studies aimed at developing tools and biomarkers for progression and prognosis, identifying clinically relevant phenotypic characteristics, and establishing clearly defined endpoints for interventional studies.
COMING SOON: HD CLARITY
HD Clarity is a multisite cerebrospinal fluid collection initiative to facilitate therapeutic development for Huntington's Disease.
Enrollment Coming Soon: HD Clarity aims to generate a high-quality CSF collection to evaluate biomarkers and pathways to enable development of novel treatments for HD. CSF will be matched with blood samples and Enroll-HD assessment data. Participants interested in joining the HD Clarity study who are between 18 and 75 years old and willing to undergo a Lumbar Puncture should not hesitate to call our center at 858-249-0569 and see if you are due for your next Enroll-HD appointment!
Enrollment Closed
DIMENSION
DIMENSION (Sage Therapeutics) was a randomized, multicenter, double-blind, placebo-controlled
phase II clinical trial to evaluate the efficacy and safety of the compound SAGE-718 in early
Huntington's Disease patients.
ENROLLMENT CLOSED: The purpose of the study was to evaluate the efficacy and safety of SAGE-718
in early-HD subjects. The study lasted approximately 3-4 months per participant.
PURVIEW
PURVIEW (Sage Therapeutics) was an open-label Phase 3 safety study of SAGE-718 in people with HD cognitive impairment.
ENROLLMENT CLOSED: The study aimed to evaluate the long-term safety profile and compare performance against HD natural history studies in subjects who previously participated in the DIMENSION study. Enrollment for subjects is currently closed.
Study Completed
KINECT-HD2
KINECT-HD2 (Neurocrine) was a randomized, multicenter, open-label phase III clinical trial to evaluate the efficacy and safety of the orally active VMAT2 inhibitor Valbenazine in Huntington's Disease patients. The study is looking to recruit HD participants between the ages of 18-75 who are exhibiting chorea.
STUDY COMPLETED: The purpose of the study was to evaluate the long-term efficacy and safety of Valbenazine in HD subjects.
PROOF-HD
PROOF-HD was a randomized, multicenter, double-blind, placebo controlled, phase III study, conducted by Prilenia Therapeutics, evaluating the efficacy and safety of Pridopidine in patients with early stage HD.
STUDY COMPLETED: The purpose of the study was to evaluate the efficacy, safety, biomarker effects, and functional maintenance of Pridopidine compared with placebo in subjects with early stage HD.
Triplet's Shield HD
Triplet's SHIELD-HD study is a observational study that investigated how Huntington's Disease progresses over time.
STUDY COMPLETED: The purpose of the study was to observe disease progression for patients with varying manifestations of Huntington's Disease. Key findings may be used to help researchers initiate genetic therapies for HD.
GENERATION HD1
A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Patients with Manifest Huntington's Disease.
STUDY COMPLETED
PRECISION-HD2
PRECISION-HD2 is a Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single dose of WVE-120102 in adult patients with early manifest Huntington's disease (HD) who carry a targeted single nucleotide polymorphism (SNP) rs362331 (SNP2).
STUDY COMPLETED
VACCINEX
VACCINEX is a Phase 2, Multi-center, Randomized, Double-blind, Placebo Controlled Study in Subjects With Late Prodromal and Early Manifest Huntington Disease (HD) to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of VX15/2503
STUDY COMPLETED
ENROLL-HD
ENROLL-HD: A Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Laquinimod (0.5, 1.0 and 1.5 mg/day) as Treatment in Patients with Huntington's Disease
STUDY COMPLETED
STUDY COMPLETED
OMEROS
OMEROS: Phase 2 Randomized, Double-Blind, Placebo-Controlled, Sequential, Cohort Study to Evaluate Safety and Efficacy of OMS643762 in Subjects with Huntington’s Disease
STUDY COMPLETED
Pride-HD
Pride-HD: A Phase 2, Dose-Finding, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Study, Evaluating the Safety and Efficacy of Pridopidine 45 mg, 67.5 mg, 90 mg, and 112.5 mg Twice-Daily Versus Placebo for Symptomatic Treatment in Patients With Huntington's Disease
STUDY COMPLETED
Reach2HD
Reach2HD: A randomized, double-blind, placebo-controlled study to assess the safety and tolerability, and efficacy of PBT2 in patients with early to mid-stage Huntington disease.
STUDY COMPLETED
SIENABIOTECH
SIENABIOTECH: Open-label Food Effect Study With SEN0014196 in Subjects With Huntington’s Disease
STUDY COMPLETED
Enrollment Closed
vUHDRS
Huntington’s Study Group’s vUHDRS is an observational study that is investigating how
Huntington's Disease patients can manage having longitudinal neuropsychiatric testing done
virtually.
ENROLLING NOW: The purpose of the study is to observe participation for patients with
varying manifestations of Huntington's Disease. Key findings may help implement virtual visits
for testing where needed for patients who were previously unable to participate in longitudinal
studies.
COHORT
Study Completed
Prospective Memory Deficits in HD
STUDY COMPLETED: A single-center, observational study designed to identify a fundamental, yet relatively unexamined, memory deficit that may affect the execution of various daily living skills in individuals diagnosed with HD. A paper-and-pencil prospective memory task will be administered to subjects with early manifest HD and non-HD control subjects. Eligible subjects will be between the ages of 35 and 75. Participation will require one visit. The study will be conducted at UCSD. Approximately 40 subjects will be enrolled.
Temporal Order Memory Deficits in HD
STUDY COMPLETED: A single-center, observational study designed to identify a processing deficit that may affect the execution of various daily living skills in individuals diagnosed with HD. A computerized visuospatial temporal order memory task will be administered to subjects with early manifest HD and non-HD control subjects. Eligible subjects will be between the ages of 35 and 75. Participation will require one visit. The study will be conducted at UCSD. Approximately 40 subjects will be enrolled.
Assessment of Basal Ganglia Signaling Pathways Affected in HD
STUDY COMPLETED