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Dore Lab Publications

K. Prinkey, E. Thompson, J. Saikia, T. Cid and K. Dore (2024) Fluorescence lifetime imaging of AMPA receptor endocytosis in living neurons: effect of Aβ and PP1. Frontiers in Molecular Neuroscience. 17. https://doi.org/10.3389/fnmol.2024.1409401

M. Manikkoth, K. Dore (2024) Live FRET-FLIM imaging to study metabotropic signaling via the NMDA receptor. New Technologies for Glutamate Interactions: Neurons and Glia, NeuroMethods Book series, Springer Nature.

A.Q. Pham, K. Dore. (2022) Novel approaches to increase synaptic resilience as potential treatments for Alzheimer’s disease. Seminars in Cell and Developmental Biology. Published online on 3/31/2022. https://www.sciencedirect.com/science/article/pii/S1084952122001148?dgcid=author

Lordén, G., Wozniak, J.M., Doré, K. et al. Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model. Nat Commun 13, 7200 (2022). https://doi.org/10.1038/s41467-022-34679-7

K. Dore1, Z. Carrico, S. Alfonso, M. Marino, K. Koymans, H. Kessels, R. Malinow. (2021) PSD-95 protects synapses from β-amyloid. Cell Reports, 35, 109194. https://doi.org/10.1016/j.celrep.2021.109194. 1- Corresponding author

K. Dore1 and Roberto Malinow. (2021) Elevated PSD-95 blocks ion-flux independent LTD: a new role for PSD-95 in synaptic plasticity. Neuroscience, 456:43-49. doi: 10.1016/j.neuroscience.2020.02.020. Epub 2020 Feb 28. 1- Corresponding author

K. Dore, Y. Pao, J. S. Lopez, S. Aronson, H. Zhan, S. Ghosh, S. Merrill, A. M. Zador, R. Malinow, J. M. Kebschull. (2020) SYNPLA, a method for identifying synapses displaying plasticity after learning. Proc Natl Acad Sci U S A., 117 (6) 3214-3219, https://doi.org/10.1073/pnas.1919911117

K. Sapoka, K. Dore, K. Tang, M. Irvine, G. Fang, E.S. Burnell, R. Malinow, D.E. Jane, D.T. Monaghan. (2019) The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators. Biochem Pharmacol., 159:140-153.

K. Dore, I.S. Stein, J.A. Brock, P.E Castillo, K. Zito, P.J. Sjöström. (2017) Unconventional NMDA receptor signaling. Journal of Neuroscience 37 (45), 10800-10807.

K. Dore, J. Aow, R. Malinow. (2016) The emergence of NMDA receptor metabotropic function: insights from imaging. Frontiers in synaptic neuroscience. 8:20. doi: 10.3389/fnsyn.2016.00020.

K. Dore, J. Aow, R. Malinow. (2015) Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow. Proc Natl Acad Sci U S A. 112(47): 14705-14710.

J. Aow1, K. Dore1, R. Malinow. (2015) Conformational signaling required for synaptic plasticity by the NMDAR complex. Proc Natl Acad Sci U S A. 112(47): 14711-14716. 1- Authors contributed equally

L-C.L. Tsai, L. Xie, K. Dore, L. Xie, J.C. Del Rio, C.C. King, G. Martinez-Ariza, C. Hulme, R. Malinow, P.E. Bourne, A.C. Newton. (2015) Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. Journal of Biological Chemistry. 290 (36), 21845-21856

K. Dore, S. Labrecque, C. Tardif, P. De Koninck. (2014) FRET-FLIM Investigation of PSD95-NMDA Receptor Interaction in Dendritic Spines; Control by Calpain, CaMKII and Src Family Kinase. PloS one. 9(11):e112170.

J.L. Swift, A.G. Godin, K. Dore, L. Freland, N. Bouchard, C. Nimmo, M. Sergeev, Y. De Koninck, P.W. Wiseman, J.M. Beaulieu (2011) Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells. Proc Natl Acad Sci U S A, 108(17):7016-21.