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Department of Neurosciences Department of Neurosciences
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Timeline

 February 2026: 

  • Our paper describing how PSD-95 palmitoylation is specifically reduced in female AD model mice and how restoring its palmitoylation using Palm B can rescue memory and synaptic deficits is finally out at Communications Biology. Check it out! https://www.nature.com/articles/s42003-026-09702-y

 December 2025: 

  • Maureen defends her Master’s thesis on PKC alpha trafficking in AD model mice neurons and interactions with synaptic scaffolds. Great job Maureen!

    -Kim visits the Nencki Institute in Warsaw, Poland and gives a seminar about the lab’s research on PSD-95.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

November 2025

  • The lab presents three posters at the SFN meeting in downtown San Diego. Yixing shows her work on LTD in young and aged mice, Maureen her work on PKC and Haritha, Claire and Sofia a poster about ABHD17 knockdown in vivo to rescue deficits in AD model mice. Awesome work everyone!

 

August 2025:

The lab participates to the AD research day at USC’s ATRI. Maureen, Amber and Yixing give oral presentations. Yixing wins the best talk award!

 

 

July 2025: 

  • Haritha defends her master's thesis. She is the first MS student to graduate from the lab. Big congratulations! Excellent work!

     

June 2025: 

  • We receive an Administrative Supplement grant from the NIA to replace our two-photon laser. 
  • We welcome two new undergraduate researchers, Sam and Sofia. 
  • Haritha presents her Master's project at the Biology Research Showcase and wins second place, congrats Haritha!  
May 2025: 

  • The lab presents three posters and Dr. Dore gives a seminar during UC Irvine's Center For the Neurobiology of Learning and Memory Spring Conference. 

 

April 2025: 

  • Paper from our collaborative work with the Sigurdson lab is out in Journal of Clinical Investigation https://www.jci.org/articles/view/186432/ga

  • Nicole, Amber and Celeste present at the Undergraduate Research Conference. Congrats!


January 2025: 

  • Roger Tsien Symposium, Maureen presents a poster on her project about the role of PKC in Alzheimer's disease, she wins best poster award!

  • Lab welcomes two new undergraduate researchers, Son and Deen
November 2024:
  • The lab moved from the Center for Neural Circuits and Behavior (CNCB) to the 3rd floor of the Medical Teaching Facilities (MTF) building. Come see our new lab in rooms 325-328!
October 2024:
  • Yixing, Celeste and Nessa present at SFN 2024 in Chicago
  • Dr. Dore gives a seminar on PSD-95 palmitoylation during a minisymposium on 'Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders' at SFN in Chicago.
  • Our review on the same topic is published in Journal of Neuroscience too: https://www.jneurosci.org/content/44/40/e1225242024.long
August 2024: July 2024:
  • Dr. Dore presents a poster and attends the FASEB conference on Protein Lipidation: Enzymology, Signaling, Therapeutics in Tucson, Arizona.

June 2024
  • First original research paper from the Dore lab published in Frontiers in Molecular Neurosciences
  • Lab party at La Jolla Shores to celebrate the departure of our awesome lab assistant Katie. Thank you so much for those two years in the lab Katie, we already miss you.
  • We also celebrate Tania and Emily who just graduated and are leaving the lab to pursue a master's degree (Emily) and to work in the biotech industry (Tania). Good luck in your future endeavors!
  • We welcome two new undergraduate researchers in the lab: Amber and Nissa
May 2024
  • Haritha and Maureen are accepted in the BS/MS program to continue their research in the lab, congratulations!
April 2024
  • Katie presents our research on PSD-95 palmitoylation at the UCSD Neurodegeneration meeting
  • Nicole Castro, a biochemistry major, joins the lab as an undergraduate researcher, welcome Nicole!
  • Celeste, Haritha and Maureen present their research at the Undergraduate Research Conference (URC) Congrats!
March 2024

January 2024

  • Bowling lab holiday party; we also celebrate the departure of two amazing undergrads, Ian and Dina who worked on fluorescence lifetime imaging (Ian) and the APOE project (Dina). Thanks for all your hard work and good luck in your future endeavors!
  • Angela Snyder joins the lab as a Research Scientist specialized in electrophysiology and imaging. Welcome Angela!
  • bowling holiday

November 2023

  • The lab welcomes four new undergraduate volunteers: Celeste, Tania, Maureen and Emily
  • Shayne presents a poster at SFN in Washington D.C. on long-term depression in APP/PS1 mice
  • shayne presenting
September 2023
  • Dr. Hemanth Kumar Boyina receives a 6-months fellowship to work in the Dore lab on characterizing a protective mutation in the depalmitoylating enzyme ABHD17a. Welcome Hemanth!
August 2023
  • Katie, Dina and Shayne present at the 'Summer Research Conference'
  • presenters
  • The lab hosts STARTneuro scholars for their capstone research projects

June 2023
  • Andrew and Mey leave the lab to pursue their dream of becoming doctors. Andrew will start medical school at UCSF and Mey at the University of Michigan. Congratulations to you two and the biggest thank you for all you've done for the lab!!!
  • Lab BBQ to celebrate Andrew and Meylab bbq
  • Katie becomes our new lab assistant after graduating and being an awesome volunteer for more than a year. Welcome Katie!
January 2023
  • Yixing Du joins the lab as a Research Scientist specialized in electrophysiology. Welcome Yixing!
  • Dr. Dore is now a core faculty member of the STARTneuro program.

December 2022

  • Dr. Dore is now officially an Assistant Professor! 
  • Andrew presents a poster at the 'Roger Tsien Cell Signaling Symposium'.    

November 2022

  • Paper on an Alzheimer's disease-associated variant of protein kinase C is now published in Nature communications (collaboration with the Newton lab)
  • Mehreen who finished her undergraduate studies in May 2022 is now a 'Neurosciences Lab Assistant'. Congrats and thanks for all your hard work Mey!  
  • Several members of the lab attend SFN 2022, Dr. Dore presents a poster with title: Blocking PSD-95 depalmitoylation rescues memory deficits in female APP/PS1 mice but not in males. 

October 2022

  • Dina Kianiazar and Haritha Karthikeyan join the lab as undergraduate volunteers. Welcome to the Dore lab! 
  • Dr. Dore is an invited speaker at West Virginia University (WVU). Talk title: Increasing PSD-95 palmitoylation, a way to prevent synaptic loss. 

August 2022

  • Dr. Dore attends the International Society for Neurochemistry (ISN) conference in Honolulu, Hawaii and gives a conference in a symposium on NMDA receptors along with Profs. Jesper Sjostrom and Roger Thompson. Talk title: Metabotropic NMDA receptor signaling in Alzheimer's disease.  

 ISN 2022

Summer 2022

  • Jenna Dohner from UC Davis is a summer intern. Katie Prinkey joins the lab as a volunteer. 

March 2022

December 2021

  • Dr. Dore is an invited speaker at CERVO research center in Quebec city, Canada. Talk title: Targeting PSD-95 palmitoylation in Alzheimer's disease.

November 2021

  • Dr. Dore presents a special seminar at UCSD's Neurosciences department

October 2021

  • Dr. Dore attends and presents a poster at the 'New horizons in AD' conference in Leuven, Belgium

August 2021

  • Mehreen Manikkoth joins the lab as an undergraduate volunteer

June 2021

May 2021

  • Dr. Dore R01 grant on PSD-95 palmitoylation is awarded!
  • Andrew Pham is hired as a Staff Research Associate