Skip to main content

Hnasko Lab Publications


Warlow SM, Zell V, Hunker AC, Zweifel LS, Hnasko TS. Mesoaccumbal glutamate neurons drive reward via glutamate release, but aversion via dopamine co-release. pre-print on bioRxiv.


Souter EA, Chen YC, Zell V, Lallai V, Steinkellner T, Conrad WS, Wisden W, Harris KD, Fowler CD, Hnasko TS. Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration. eNeuro
pre-print on bioRxiv

Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson’s disease. Brain

Maimon R, Chillon-Marinas C, Snethlage CE, Singhal SM, McAlonis-Downes M, Ling K, Rigo F, Bennett CF, Da Cruz S, Hnasko TS, Muotri AR, Cleveland DW. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nature Neuroscience

Buck SA, Steinkellner T, Aslanoglou D, Villeneuve M, Bhatte SH, Childers VC, Rubin SA, De Miranda BR, O'Leary EI, Neureiter EG, Fogle KJ, Palladino MJ, Logan RW, Glausier JR, Fish KN, Lewis DA, Greenamyre JT, McCabe BD, Cheetham CEJ, Hnasko TS, Freyberg Z. Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration. Aging Cell
pre-print on bioRxiv

Farrell MR, Esteban JSD, Faget L, Floresco SB, Hnasko TS, Mahler SV. Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice. Journal of Neuroscience
pre-print on bioRixv

Renteria R, Cazares C, Baltz ET, Schreiner DC, Yalcinbas EA, Steinkellner T, Hnasko TS, Gremel CM.
Mechanism for differential recruitment of orbitostriatal transmissino during actions and outcomes following chronic alcohol exposure. eLife
pre-print on bioRxiv

Steinkellner T, Madany M, Haberl MG, Zell V, Li C, Hu J, Mackey M, Ramachandra R, Adams S, Ellisman MH, Hnasko TS*, Boassa DB*. Genetic probe for visualizing glutamatergic synapses and vesicles by 3D electron microscopy.  ACS Chemical Neuroscience   *equal contributions
pre-print on bioRxiv 


Zell V, Steinkellner T, Hollon NG, Souter E, Faget L, hunker A, Jin X, Zweifel LS, Hnasko TS. VTA glutamate neuron activity drives positive reinforcement absent dopamine co-release. Neuron

Heston JB, Friedman A, Bagai M, Bavafa N, Aron AR, Hnasko TS. Activation of the subthalamic nucleus stop circuit disrupts cognitive performance. eNeuro

Khom S, Steinkellner T, Hnasko TS, Roberto M. Alcohol dependence potentiates Substance P/Neurokinin 1 receptor signaling in the rat central nucleus of amygdala. Science Advances

Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis X, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sorensen J, Cador M, Fioramonti X, Tschop MH, Laye S, Vernance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH. Circulating triglycerides gate dopamine-associated behaviors through dopamine receptor type 2-expressing neurons. Cell Metabolism


Farrell MR, Ruiz CM, Castillo E, Faget L, Khanbijian C, Liu S, Schoch H, Rojas G, Huerta MY, Hnasko TS, Mahler SV. Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats. Neuropsychopharmacology

Steinkellner T, Yoo JH, Hnasko TS. Differential expression of VGLUT2 in mouse mesopontine cholinergic neurons. eNeuro

Romoli B, Lozada AF, Sandoval IM, Manfredsson FP, Hnasko TS, Berg DK, Dulcis D. Neonatal nicotine exposure primes midbrain neurons to dopaminergic phenotype and increasess adult drug consumption. Biological Psychiatry

Bimpisidis Z, Konig N, Stagkourakis S, Zell V , Vlcek B, Dumas S, Giros B, Broberger C, Hnasko TS, Wallen-Mackenzie A. The NeuroD6 subtype of VTA neurons contributes to psychostimulant sensitization and behavioral reinforcement. eNeuro


Faget L*, Zell V*, Souter, E, McPherson A, Ressler, R, Gutierrez-Reed N, Yoo JH, Dulcis D, Hnasko TS.
Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum. Nature Communications   *equal contributions

Steinkellner T, Zell V, Farino ZJ, Sonders MS, Villeneuve M, Freyberg RJ, Przedborski S, Lu W, Freyberg Z, Hnasko TS. Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. Journal of Clinical Investigation


Fife HA, Gutierrez-Reed NA, Zell V, Bailly J, Lewis C, Aron AR, Hnasko TS. Causal role for the subthalamic nucleus in interrupting behavior. eLife

Wang DV, Viereckel T, Konradsson-Geuken A, Broker CJ, Talishinsky A, Yoo JH, Galinato MH, Arvidsson E, Hnasko TS, Wallén-Mackenzie A, Ikemoto S. Glutamate co-transmission does not potentiate acquisition of conditioned behavior reinforced by dopamine neuron activation. Cell Reports

Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA, Lu W. Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high effort behavior.  Molecular Psychiatry

Yoo JH, Zell V, Wu J, Punta C, Ramajayam N, Shen X, Lilascharoen V, Lim BK, Hnasko TS. Activation of pedunculopontine glutamate neurons is reinforcing. Journal of Neuroscience


Yoo JH*, Zell V*, Gutierrez-Reed N, Wu J, Ressler R, Shenasa MA, Johnson AB, Fife KH, Faget L, Hnasko TS. Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement. Nature Communications   *equal contributions

Faget L, Osakada F, Duan J, Ressler R, Johnson AB, Yoo JH, Proudfoot JA, Callaway EM, Hnasko TS. Afferent inputs to neurotransmitter-defined cell types in the ventral tegmental area. Cell Reports

Soden ME, Miller SM, Burgeno LM, Phillips PEM, Hnasko TS, Zweifel LS. Genetic isolation of hypothalamic neurons that regulate context-specific male social behavior. Cell Reports

Berland C, Cansell C, Hnasko TS, Magnan C, Luquet S. Dietary triglycerides as signaling molecules that influence reward and motivation. Current Opinion in Behavioral Sciences


Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA. Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output. Molecular Metabolism

Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler A, Magnan C, Luquet S. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metabolism


Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. Journal of Neuroscience

Trudeau LE, Hnasko TS, Wallén-Mackenzie A, Morales M, Rayport S, Sulzer D. The multilingual nature of dopamine neurons. Progress in Brain Research

Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, Dileone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S. Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Molecular Psychiatry


Delwig A, Majumdar S, Ahern K, LaVail MM, Edwards RH, Hnasko TS, Copenhagen DR. Glutamatergic neurotransmission from melanopsin retinal ganglion cells is required for neonatal photoaversion but not adult pupillary light reflex. PLOS One

Li H, Fertuzinhos S, Mohns E, Hnasko TS, Edwards RH, Sestan N, Crair MC. Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron

Bui TV, Akay T, Loubani O, Hnasko TS, Jessell TM, Brownstone RM. Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior. Neuron


Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH. Ventral Tegmental Area Glutamate Neurons: Electrophysiological Properties and Projections. The Journal of Neuroscience

Hnasko TS, Edwards RH. Neurotransmitter co-release: mechanism and physiological role. Annual Reviews in Physiology


Talapor AE, Endo T, Low P, Borgius L, Hagglund M, Dougherty KJ, Ryge J, Hnasko TS, Kiehn O. Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord. Neuron

Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH. Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. Nature Neuroscience

Koch SM, Dela Cruz SG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM. Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron


Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Hnasko TS, Edwards RH, Basbaum AI. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and heat hypersensitivity following peripheral injury. Proceedings of the National Academy of Sciences USA

*Stuber G, *Hnasko TS, Britt J, Edwards RH, Bonci A. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum co-release glutamate. Journal of Neuroscience  *equal contributions

Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron


Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proceedings of the National Academy of Sciences


*Hnasko TS, *Sotak BA, Palmiter RD. Cocaine conditioned place preference in dopamine-deficient mice is mediated by serotonin. Journal of Neuroscience  *equal contributions

Hnasko TS, Hnasko RM, Sotak BN, Kapur RP, Palmiter RD. Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia. Neuroendocrinology

Robinson S, Rainwater AJ, Hnasko TS, Palmiter RD.Viral restoration of dopamine signaling to the dorsal striatum restores instrumental conditioning to dopamine-deficient mice. Psychopharmacology


Hnasko TS, Perez FA, Scouras A, Stoll EA, Luquet S, Gale SD, Phillips PE, Kremer EJ, Palmiter RD.
Cre-recombinase mediated restoration of dopamine production to the dorsal striatum results in hyperphagia and hyperactivity.  PNAS


Hnasko TS, Sotak BA, Palmiter RD. Morphine reward in dopamine-deficient mice. Nature

Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science

Sotak BA, Hnasko TS, Robinson S, Kremer EJ, Palmiter RD.Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding. Brain Research


Hnasko TS, Szczypka MS, Alaynick WA, During MJ, Palmiter RD. A role for dopamine in feeding responses produced by orexigenic agents. Brain Research


Heusner CA, Hnasko TS, Szczypka MS, Liu Y, During MJ, Palmiter RD. Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine. Brain Research