Hnasko Lab Publications
2025
Oriol L, Chao M, Kollman G, Dowlat DS, Singhal SM, Steinkellner T, Hnasko TS.
eLife PDF
eLife
Srinivasan S, Limani F, Hanzlova M, La Batide-Alanore S, Klotz S, Hnasko TS, Steinkellner T.
Evidence for low affinity of GABA at the vesicular monoamine transporter VMAT2 - Implications for transmitter co-release from dopamine neurons
Neuropharmacology PDF
Neuropharmacology
2024
Singhal SM, Szlaga A, Chen YC, Conrad WS, Hnasko TS.
Mu-opioid receptor activation potentiates excitatory transmission at the habenulo-peduncular synapse.
pre-print on bioRxiv.
2023
Buck SA, Rubin SA, Kunkhyen T, Treiber CD, Xue X, Fenno LE, Mabry SJ, Sundar VR, Yang Z, Shah D, Ketchesin KD, Becker-Krail DD, Vasylieva I, Smith MC, Weisel FJ, Wang W, Erickson-Oberg MQ, O'Leary EI, Aravind E, Ramakrishnan C, Kim YS, Wu Y, Quick M, Coleman JA, MacDonald WA, Elbakri R, De Miranda BR, Palladino MJ, McCabe BD, Fish KN, Seney ML, Rayport S, Mingote S, Deisseroth K, Hnasko TS, Awatramani R, Watson AM, Waddell S, Cheetham CEJ, Logan RW, Freyberg Z.
Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration.
pre-print on bioRxiv
2022
2021
Ventral Pallidum GABA Neurons Mediate Motivation Underlying Risky Choice.
Journal of Neuroscience PDF
Journal of Neuroscience
bioRixv
Renteria R, Cazares C, Baltz ET, Schreiner DC, Yalcinbas EA, Steinkellner T, Hnasko TS, Gremel CM.
Mechanism for differential recruitment of orbitostriatal transmissino during actions and outcomes following chronic alcohol exposure.
eLife PDF
eLife
bioRxiv
Steinkellner T, Madany M, Haberl MG, Zell V, Li C, Hu J, Mackey M, Ramachandra R, Adams S, Ellisman MH, Hnasko TS*, Boassa DB*.
*co-corresponding authors
Genetic probe for visualizing glutamatergic synapses and vesicles by 3D electron microscopy.
ACS Chemical Neuroscience PDF
ACS Chemical Neuroscience
bioRxiv
2020
Zell V, Steinkellner T, Hollon NG, Souter E, Faget L, hunker A, Jin X, Zweifel LS, Hnasko TS.
VTA glutamate neuron activity drives positive reinforcement absent dopamine co-release.
Neuron PDF
Neuron
Heston JB, Friedman A, Bagai M, Bavafa N, Aron AR, Hnasko TS.
Activation of the subthalamic nucleus stop circuit disrupts cognitive performance.
eNeuro PDF
eNeuro
Khom S, Steinkellner T, Hnasko TS, Roberto M.
Alcohol dependence potentiates Substance P/Neurokinin 1 receptor signaling in the rat central nucleus of amygdala.
Science Advances PDF
Science Advances
Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis X, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sorensen J, Cador M, Fioramonti X, Tschop MH, Laye S, Vernance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH.
Circulating triglycerides gate dopamine-associated behaviors through dopamine receptor type 2-expressing neurons.
Cell Metabolism PDF
Cell Metabolism
2019
Farrell MR, Ruiz CM, Castillo E, Faget L, Khanbijian C, Liu S, Schoch H, Rojas G, Huerta MY, Hnasko TS, Mahler SV.
Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats.
Neuropsychopharmacology PDF
Neuropsychopharmacology
Steinkellner T, Yoo JH, Hnasko TS.
Differential expression of VGLUT2 in mouse mesopontine cholinergic neurons.
eNeuro PDF
eNeuro
Romoli B, Lozada AF, Sandoval IM, Manfredsson FP, Hnasko TS, Berg DK, Dulcis D.
Neonatal nicotine exposure primes midbrain neurons to dopaminergic phenotype and increasess adult drug consumption.
Biological Psychiatry PDF
Biological Psychiatry
Bimpisidis Z, Konig N, Stagkourakis S, Zell V , Vlcek B, Dumas S, Giros B, Broberger C, Hnasko TS, Wallen-Mackenzie A.
The NeuroD6 subtype of VTA neurons contributes to psychostimulant sensitization and behavioral reinforcement.
eNeuro PDF
eNeuro
2018
Faget L*, Zell V*, Souter, E, McPherson A, Ressler, R, Gutierrez-Reed N, Yoo JH, Dulcis D, Hnasko TS.
*equal contributions
Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum.
Nature Communications PDF
Nature Communications
Steinkellner T, Zell V, Farino ZJ, Sonders MS, Villeneuve M, Freyberg RJ, Przedborski S, Lu W, Freyberg Z, Hnasko TS.
Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons.
Journal of Clinical Investigation PDF
Journal of Clinical Investigation
2017
Fife HA, Gutierrez-Reed NA, Zell V, Bailly J, Lewis C, Aron AR, Hnasko TS.
Causal role for the subthalamic nucleus in interrupting behavior.
eLife PDF
eLife
Wang DV, Viereckel T, Konradsson-Geuken A, Broker CJ, Talishinsky A, Yoo JH, Galinato MH, Arvidsson E, Hnasko TS, Wallén-Mackenzie A, Ikemoto S.
Glutamate co-transmission does not potentiate acquisition of conditioned behavior reinforced by dopamine neuron activation.
Cell Reports PDF
Cell Reports
Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA, Lu W.
Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high effort behavior.
Molecular Psychiatry PDF
Molecular Psychiatry
Yoo JH, Zell V, Wu J, Punta C, Ramajayam N, Shen X, Lilascharoen V, Lim BK, Hnasko TS.
Activation of pedunculopontine glutamate neurons is reinforcing.
Journal of Neuroscience PDF
Journal of Neuroscience
2016
Yoo JH*, Zell V*, Gutierrez-Reed N, Wu J, Ressler R, Shenasa MA, Johnson AB, Fife KH, Faget L, Hnasko TS.
*equal contributions
Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement.
Nature Communications PDF
Nature Communications
Faget L, Osakada F, Duan J, Ressler R, Johnson AB, Yoo JH, Proudfoot JA, Callaway EM, Hnasko TS.
Afferent inputs to neurotransmitter-defined cell types in the ventral tegmental area.
Cell Reports PDF
Cell Reports
Soden ME, Miller SM, Burgeno LM, Phillips PEM, Hnasko TS, Zweifel LS.
Genetic isolation of hypothalamic neurons that regulate context-specific male social behavior.
Cell Reports PDF
Cell Reports
Berland C, Cansell C, Hnasko TS, Magnan C, Luquet S.
Dietary triglycerides as signaling molecules that influence reward and motivation.
Current Opinion in Behavioral Sciences PDF
Current Opinion in Behavioral Sciences
2015
Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA.
Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output.
Molecular Metabolism PDF
Molecular Metabolism
Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler A, Magnan C, Luquet S.
Palatability Can Drive Feeding Independent of AgRP Neurons.
Cell Metabolism PDF
Cell Metabolism
2014
Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K.
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.
Journal of Neuroscience PDF
Journal of Neuroscience
Trudeau LE, Hnasko TS, Wallén-Mackenzie A, Morales M, Rayport S, Sulzer D.
The multilingual nature of dopamine neurons.
Progress in Brain Research PDF
Progress in Brain Research
Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, Dileone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S.
Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding.
Molecular Psychiatry PDF
Molecular Psychiatry
2013
Delwig A, Majumdar S, Ahern K, LaVail MM, Edwards RH, Hnasko TS, Copenhagen DR.
Glutamatergic neurotransmission from melanopsin retinal ganglion cells is required for neonatal photoaversion but not adult pupillary light reflex.
PLOS One PDF
PLOS One
Li H, Fertuzinhos S, Mohns E, Hnasko TS, Edwards RH, Sestan N, Crair MC.
Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission.
Neuron PDF
Neuron
Bui TV, Akay T, Loubani O, Hnasko TS, Jessell TM, Brownstone RM.
Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior.
Neuron PDF
Neuron
2012
Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH.
Ventral Tegmental Area Glutamate Neurons: Electrophysiological Properties and Projections.
The Journal of Neuroscience PDF
The Journal of Neuroscience
Hnasko TS, Edwards RH.
Neurotransmitter co-release: mechanism and physiological role.
Annual Reviews in Physiology PDF
Annual Reviews in Physiology
2011
Talapor AE, Endo T, Low P, Borgius L, Hagglund M, Dougherty KJ, Ryge J, Hnasko TS, Kiehn O.
Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord.
Neuron PDF
Neuron
Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH.
Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport.
Nature Neuroscience PDF
Nature Neuroscience
Koch SM, Dela Cruz SG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM.
Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement.
Neuron PDF
Neuron
2010
Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Hnasko TS, Edwards RH, Basbaum AI.
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and heat hypersensitivity following peripheral injury.
Proceedings of the National Academy of Sciences USA PDF
Proceedings of the National Academy of Sciences USA
*Stuber G, *Hnasko TS, Britt J, Edwards RH, Bonci A.
*equal contributions
Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum co-release glutamate.
Journal of Neuroscience PDF
Journal of Neuroscience
Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH.
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo.
Neuron PDF
Neuron
2009
Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C.
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.
Proceedings of the National Academy of Sciences PDF
Proceedings of the National Academy of Sciences
2007
*Hnasko TS, *Sotak BA, Palmiter RD.
*equal contributions
Cocaine conditioned place preference in dopamine-deficient mice is mediated by serotonin.
Journal of Neuroscience PDF
Journal of Neuroscience
Hnasko TS, Hnasko RM, Sotak BN, Kapur RP, Palmiter RD.
Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia.
Neuroendocrinology PDF
Neuroendocrinology
Robinson S, Rainwater AJ, Hnasko TS, Palmiter RD.
Viral restoration of dopamine signaling to the dorsal striatum restores instrumental conditioning to dopamine-deficient mice.
Psychopharmacology PDF
Psychopharmacology
2006
Hnasko TS, Perez FA, Scouras A, Stoll EA, Luquet S, Gale SD, Phillips PE, Kremer EJ, Palmiter RD.
Cre-recombinase mediated restoration of dopamine production to the dorsal striatum results in hyperphagia and hyperactivity.
PNAS PDF
PNAS
2005
Hnasko TS, Sotak BA, Palmiter RD.
Morphine reward in dopamine-deficient mice.
Nature PDF
Nature
Luquet S, Perez FA, Hnasko TS, Palmiter RD.
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.
Science PDF
Science
Sotak BA, Hnasko TS, Robinson S, Kremer EJ, Palmiter RD.
Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding.
Brain Research PDF
Brain Research
2004
Hnasko TS, Szczypka MS, Alaynick WA, During MJ, Palmiter RD.
A role for dopamine in feeding responses produced by orexigenic agents.
Brain Research PDF
Brain Research
2003
Heusner CA, Hnasko TS, Szczypka MS, Liu Y, During MJ, Palmiter RD.
Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine.
Brain Research PDF
Brain Research