Events & Updates
New Microscopy Core Resources
Multiphoton Microscopy
Our newly available Evident FV5000 upright multiphoton microscope is designed to support demanding imaging applications with:
• Deep tissue multiphoton imaging for intact biological samples
• Simultaneous multicolor acquisition for dynamic experiments
• Reduced photobleaching and phototoxicity during long-term imaging with fast imaging speeds
• SHG/THG label-free imaging capabilities
• Flexible excitation options for diverse fluorophore panels
Applications include:
- In vivo neuroscience imaging
- Calcium imaging and neural dynamics
- Tumor microenvironment studies
- Organoid and developmental biology workflows
- Thick tissue and cleared sample imaging
Researchers are using multiphoton workflows to capture biological processes that are difficult to resolve with traditional confocal approaches, including long-duration imaging in living tissue and high-resolution imaging at greater depths. The system is also equipped with single photon confocal abilities and great for standard sample preparations.
We would be happy to schedule:
• A live demonstration
• Sample evaluation imaging
• An application-focused discussion for your workflow
• A technical consultation with an imaging specialist
If you are exploring new approaches for deep tissue or live-cell imaging, we welcome the opportunity to discuss how the FV5000 platform may support your research goals.
We have several exciting seminars and hands-on workshops coming up this fall. These events are a great opportunity to learn about the latest microscopy and image analysis technologies, see live demonstrations, and explore how these tools can support your research.
Zeiss LSM 990 Confocal with Lightfield Seminar
Lunch and Learn Oct. 9th at Noon - CNCB Large Conference Room
Register for Lunch and Learn Here
Onsite Workshop: October 26 – November 6
CMME Microscopy Core
Register to be contacted for a Demo Slot Here
Learn about the Zeiss LSM 990 with Lightfield 4D, an exciting new technology that captures entire 3D volumes with a single snapshot. The system will be available onsite for live demonstrations.
Lightfield 4D enables instant volumetric imaging at high speed, capturing up to 80 volumes per second while preserving complete spatial and temporal information. This technology is ideal for studying rapid biological processes such as beating hearts, blood flow, neuronal activity, and organism development in unprecedented detail.
Help Us Bring This Technology to UC San Diego
We are exploring an S10 grant opportunity to fund the acquisition of this technology for the UC San Diego Microscopy Core. To make this happen, we need pilot data and collaborators who can demonstrate how Lightfield 4D could advance their research.
If you have a project that could benefit from this technology, please contact Jennifer Santini, UCSD Microscopy Core, for a consultation. Jennifer can help you assess whether Lightfield 4D is a good fit for your research and ensure your spot at the onsite demonstration.
Your project could help provide the data and collaborative foundation needed to bring this technology to our research community.
Viventis Onsite Demonstration:
Sign up to participate in the onsite Viventis light sheet demonstration! Demos will take place from Oct. 8th - Oct. 16 in CMME Basement.
Past Seminar Links:
- Imaris Seminar: Unlocking the potential of microscopy images with IMARIS AI-powered analysis
- Zeiss 990 Airyscan Confocal and Lightfield Seminar
- Introduction to the new Evident FV5000 Multiphoton System
Citation Guidelines for Using the SOM Microscopy Core
All publications using SOM Microscopy Core resources must cite the following grant numbers:
NS047101, OD030505, OD036455
Example acknowledgment:
Microscopy imaging was performed at the UCSD SOM Microscopy Core
(NS047101, OD030505, OD036455).