Recent Publications

Zhao Y, Caron C, Chan YY, Lee CK, Xu X, Zhang J, Masubuchi T, Wu C, Bui JD, Hui E. cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8(+) T cell function and anti-tumor immunity. Immunity 2023. Epub 2023/05/10.

Yu Z, Zhang L, Cattaneo P, Guimaraes-Camboa N, Fang X, Gu Y, Peterson KL, Bogomolovas J, Cuitino C, Leone GW, Chen J, Evans SM. Increasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct. Circulation 2023;147(2):1836. Epub 2023/01/10. PMCID: PMC9988404.

Navia-Pelaez JM, Borges Paes Lemes J, Gonzalez L, Delay L, Dos Santos Aggum Capettini L, Lu JW, Goncalves Dos Santos G, Gregus AM, Dougherty PM, Yaksh TL, Miller YI. AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons. Pain 2023;164(6):e274-e85. Epub 2023/02/01. PMCID: PMC10182209.

Navia-Pelaez JM, Agatisa-Boyle C, Choi SH, Sak Kim Y, Li S, Alekseeva E, Weldy K, Miller YI. Differential Expression of Inflammarafts in Macrophage Foam Cells and in Nonfoamy Macrophages in Atherosclerotic Lesions-Brief Report. Arterioscler Thromb Vasc Biol 2023;43(2):323-9. Epub 2022/12/02. PMCID: PMC9877149.

Marfull-Oromi P, Onishi K, Han X, Yates JR, 3rd, Zou Y. The Fragile X Messenger Ribonucleoprotein 1 Participates in Axon Guidance Mediated by the Wnt/Planar Cell Polarity Pathway. Neuroscience 2023;508:76-86. Epub 2022/10/04.

Liu JJ, Xin B, Du L, Chen L, Long Y, Feng GS. Pharmaceutical SH2 domain-containing protein tyrosine phosphatase 2 inhibition suppresses primary and metastasized liver tumors by provoking hepatic innate immunity. Hepatology 2023;77(5):1512-26. Epub 2022/05/04. PMCID: PMC9948275.

Li W, Wen L, Rathod B, Gingras AC, Ley K, Lee HS. Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular development. Life Sci Alliance 2023;6(3). Epub 2022/12/28. PMCID: PMC9795039.

Kim H, Saikia J, Monte K, Ha E, Romaus-Sanjurjo D, Sanchez J, Moore A, Hernaiz-Llorens M, ChavezMartinez C, Agba C, Li H, Lusk D, Cervantes K, Zheng B. Probing regenerative heterogeneity of corticospinal neurons with scRNA-Seq. Res Sq 2023. Epub 2023/03/04. PMCID: PMC9980198.

Jin Z, Dridi N, Palui G, Palomo V, Jokerst JV, Dawson PE, Sang QA, Mattoussi H. Quantum Dot-Peptide Conjugates as Energy Transfer Probes for Sensing the Proteolytic Activity of Matrix Metalloproteinase-14. Anal Chem 2023;95(5):2713-22. Epub 2023/01/28.

Jin Z, Dridi N, Palui G, Palomo V, Jokerst JV, Dawson PE, Amy Sang QX, Mattoussi H. Evaluating the Catalytic Efficiency of the Human Membrane-type 1 Matrix Metalloproteinase (MMP-14) Using AuNPPeptide Conjugates. J Am Chem Soc 2023;145(8):4570-82. Epub 2023/02/22.

Chung C, Yang X, Bae T, Vong KI, Mittal S, Donkels C, Westley Phillips H, Li Z, Marsh APL, Breuss MW, Ball LL, Garcia CAB, George RD, Gu J, Xu M, Barrows C, James KN, Stanley V, Nidhiry AS, Khoury S,

Howe G, Riley E, Xu X, Copeland B, Wang Y, Kim SH, Kang HC, Schulze-Bonhage A, Haas CA, Urbach

H, Prinz M, Limbrick DD, Jr., Gurnett CA, Smyth MD, Sattar S, Nespeca M, Gonda DD, Imai K, Takahashi

Y, Chen HH, Tsai JW, Conti V, Guerrini R, Devinsky O, Silva WA, Jr., Machado HR, Mathern GW, Abyzov

A, Baldassari S, Baulac S, Focal Cortical Dysplasia Neurogenetics C, Brain Somatic Mosaicism N, Gleeson JG. Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development. Nat Genet 2023;55(2):209-20. Epub 2023/01/13. PMCID: PMC9961399.

Lin L, Pinto A, Wang L, Fukatsu K, Yin Y, Bamforth SD, Bronner ME, Evans SM, Nie S, Anderson RH, Terskikh AV, Grossfeld PD. ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest. Hum Mol Genet. 2022 Dec 16;31(24):4217-4227. doi: 10.1093/hmg/ddac174. PubMed PMID: 35899771.

McCurdy S, Lin J, Shenkar R, Moore T, Lightle R, Faurobert E, Lopez-Ramirez MA, Awad I, Ginsberg MH. β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations. FASEB J. 2022 Dec;36(12):e22629. doi: 10.1096/fj.202200907RR. PubMed PMID: 36349990; PubMed Central PMCID: PMC9674378.

Ramms B, Pollow DP, Zhu H, Nora C, Harrington AR, Omar I, Gordts PLSM, Wortham M, Sander M. Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity. Diabetes. 2022 Dec 1;71(12):2513-2529. doi: 10.2337/db21-1131. PubMed PMID: 36162056; PubMed Central PMCID: PMC9750949.

Geoffroy CG, Meves JM, Kim HJM, Romaus-Sanjurjo D, Sutherland TC, Li JJ, Suen J, Sanchez JJ, Zheng B. Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting. iScience. 2022 Nov18;25(11):105383. doi: 10.1016/j.isci.2022.105383. eCollection 2022 Nov 18. PubMed PMID: 36339257; PubMed Central PMCID: PMC9626739.

Aung A, Davey SK, Theprungsirikul J, Kumar V, Varghese S. Deciphering the Mechanics of Cancer Spheroid Growth in 3D Environments through Microfluidics Driven Mechanical Actuation. Adv Healthc Mater. 2022 Nov 14;:e2201842. doi: 10.1002/adhm.202201842. [Epub ahead of print] PubMed PMID: 36377350.

Gerner RR, Hossain S, Sargun A, Siada K, Norton GJ, Zheng T, Neumann W, Nuccio SP, Nolan EM, Raffatellu M. Siderophore Immunization Restricted Colonization of Adherent-Invasive Escherichia coli and Ameliorated Experimental Colitis. mBio. 2022 Oct 26;13(5):e0218422. doi: 10.1128/mbio.02184-22. Epub 2022 Sep 12. PubMed PMID: 36094114; PubMed Central PMCID: PMC9600343.

Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 Oct;610(7931):366-372. doi: 10.1038/s41586-022-05169-z. Epub 2022 Oct 5. PubMed PMID: 36198801; PubMed Central PMCID: PMC9588640.

Holland ND, Holland LZ, Somorjai IML. Three-dimensional fine structure of fibroblasts and other mesodermally derived tissues in the dermis of adults of the Bahamas lancelet (Chordata, Cephalohordata), as seen by serial block-face scanning electron microscopy. J Morphol. 2022 Oct;283(10):1289-1298. doi: 10.1002/jmor.21502. Epub 2022 Aug 15. PubMed PMID: 35971624.

Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiol Dis. 2022 Oct 1;172:105834. doi: 10.1016/j.nbd.2022.105834. Epub 2022 Jul 26. PubMed PMID: 35905927; PubMed Central PMCID: PMC10080886.

Weeks R, Zhou X, Yuan TL, Zhang J. Fluorescent Biosensor for Measuring Ras Activity in Living Cells. J Am Chem Soc. 2022 Sep 28;144(38):17432-17440. doi: 10.1021/jacs.2c05203. Epub 2022 Sep 19. PubMed PMID: 36122391; PubMed Central PMCID: PMC10031818. Romaus-Sanjurjo D, Saikia JM, Kim HJ, Tsai KM, Le GQ, Zheng B. Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury. Cell Death Discov. 2022 Sep 20;8(1):390. doi: 10.1038/s41420-022-01186-z. PubMed PMID: 36123349; PubMed Central PMCID: PMC9485247.

Barr J, Gentile ME, Lee S, Kotas ME, Fernanda de Mello Costa M, Holcomb NP, Jaquish A, Palashikar G, Soewignjo M, McDaniel M, Matsumoto I, Margolskee R,Von Moltke J, Cohen NA, Sun X, Vaughan AE. Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair. Elife. 2022 Sep 8;11. doi: 10.7554/eLife.78074. PubMed PMID: 36073526; PubMed Central PMCID: PMC9553214.

Zhao P, Sun X, Liao Z, Yu H, Li D, Shen Z, Glass CK, Witztum JL, Saltiel AR. The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis. JCI Insight. 2022 Sep 8;7(17). doi: 10.1172/jci.insight.155552. PubMed PMID: 35917178; PubMed Central PMCID: PMC9536260. Xu M,

Zhou J, Cheng Y, Jin Z, Clark AE, He T, Yim W, Li Y, Chang YC, Wu Z, Fajtová P, O'Donoghue AJ, Carlin AF, Todd MD, Jokerst JV. A Self-Immolative Fluorescent Probe for Selective Detection of SARS-CoV-2 Main Protease. Anal Chem. 2022 Aug 30;94(34):11728-11733. doi: 10.1021/acs.analchem.2c02381. Epub 2022 Aug 16. PubMed PMID: 35973073; PubMed Central PMCID: PMC9396966.

Wang L, Lin L, Qi H, Chen J, Grossfeld P. Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction. Circ Res. 2022 Aug 19;131(5):371-387. doi: 10.1161/CIRCRESAHA.121.319955. Epub 2022 Jul 27. PubMed PMID: 35894043; PubMed Central PMCID: PMC9624262.

Cobo I, Tanaka TN, Chandra Mangalhara K, Lana A, Yeang C, Han C, Schlachetzki J, Challcombe J, Fixsen BR, Sakai M, Li RZ, Fields H, Mokry M, Tsai RG, Bejar R, Prange K, de Winther M, Shadel GS, Glass CK. DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages. Immunity. 2022 Aug 9;55(8):1386-1401.e10. doi: 10.1016/j.immuni.2022.06.022. Epub 2022 Aug 4. PubMed PMID: 35931086; PubMed Central PMCID: PMC9718507.

Gamliel A, Meluzzi D, Oh S, Jiang N, Destici E, Rosenfeld MG, Nair SJ. Long-distance association of topological boundaries through nuclear condensates. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2206216119. doi: 10.1073/pnas.2206216119. Epub 2022 Aug 1. PubMed PMID: 35914133; PubMed Central PMCID: PMC9371644.

Tonsfeldt KJ, Cui LJ, Lee J, Walbeek TJ, Brusman LE, Jin Y, Mieda M, Gorman MR, Mellon PL. Female fertility does not require Bmal1 in suprachiasmatic nucleus neurons expressing arginine vasopressin, vasoactive intestinal peptide, or neuromedin-S. Front Endocrinol (Lausanne). 2022;13:956169. doi: 10.3389/fendo.2022.956169. eCollection 2022. PubMed PMID: 35992114; PubMed Central PMCID: PMC9389073.

Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 Aug 2;34(8):1201-1213.e5. doi: 10.1016/j.cmet.2022.07.006. PubMed PMID: 35921818; PubMed Central PMCID: PMC9365100.

Miller M, Pham AK, Gonen A, Navia-Pelaez JM, Xia K, Park S, Osterman AL, Bacon K, Beaton G, Kurten RC, Broide DH, Miller YI. Reduced AIBP expression in bronchial epithelial cells of asthmatic patients: Potential therapeutic target. Clin Exp Allergy. 2022 Aug;52(8):979-984. doi: 10.1111/cea.14150. Epub 2022 Apr 26. PubMed PMID: 35460293.

Luo Z, Ji Y, Zhang D, Gao H, Jin Z, Yang M, Ying W. Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis. Acta Physiol (Oxf). 2022 Jul;235(3):e13827. doi: 10.1111/apha.13827. Epub 2022 May 10. PubMed PMID: 35500155; PubMed Central PMCID: PMC9335517.

Torres A, Pedersen B, Cobo I, Ai R, Coras R, Murillo-Saich J, Nygaard G, Sanchez-Lopez E, Murphy A, Wang W, Firestein GS, Guma M. Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2022 Jul;74(7):1159-1171. doi: 10.1002/art.42077. Epub 2022 Jun 2. PubMed PMID: 35128827; PubMed Central PMCID: PMC9246826.

Wang H, Alarcón CN, Liu B, Watson F, Searles S, Lee CK, Keys J, Pi W, Allen D, Lammerding J, Bui JD, Klemke RL. Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue. Nat Biomed Eng. 2022 Jul;6(7):882-897. doi: 10.1038/s41551-021-00815-9. Epub 2021 Dec 20. PubMed PMID: 34931077; PubMed Central PMCID: PMC9207157.

Avansini SH, Puppo F, Adams JW, Vieira AS, Coan AC, Rogerio F, Torres FR, Araújo PAOR, Martin M, Montenegro MA, Yasuda CL, Tedeschi H, Ghizoni E, França AFEC, Alvim MKM, Athié MC, Rocha CS, Almeida VS, Dias EV, Delay L, Molina E, Yaksh TL, Cendes F, Lopes Cendes I, Muotri AR. Junctional instability in neuroepithelium and network hyperexcitability in a focal cortical dysplasia human model. Brain. 2022 Jun 30;145(6):1962-1977. doi: 10.1093/brain/awab479. PubMed PMID: 34957478; PubMed Central PMCID: PMC9336577.

Sedat J, McDonald A, Cang H, Lucas J, Arigovindan M, Kam Z, Murre C, Elbaum M. A proposed unified interphase nucleus chromosome structure: Preliminary preponderance of evidence. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2119101119. doi: 10.1073/pnas.2119101119. Epub 2022 Jun 24. PubMed PMID: 35749363; PubMed Central PMCID: PMC9245672.

Kanbar JN, Ma S, Kim ES, Kurd NS, Tsai MS, Tysl T, Widjaja CE, Limary AE, Yee B, He Z, Hao Y, Fu XD, Yeo GW, Huang WJ, Chang JT. The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression. J Exp Med. 2022 Jun 6;219(6). doi: 10.1084/jem.20211756. Epub 2022 May 20. PubMed PMID: 35593887; PubMed Central PMCID: PMC9127983.

Saikia JM, Chavez-Martinez CL, Kim ND, Allibhoy S, Kim HJ, Simonyan L, Smadi S, Tsai KM, Romaus-Sanjurjo D, Jin Y, Zheng B. A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord. J Neurosci. 2022 May 4;42(18):3716-3732. doi: 10.1523/JNEUROSCI.2495-21.2022. Epub 2022 Mar 31. PubMed PMID: 35361703; PubMed Central PMCID: PMC9087816.

Breuss MW, Yang X, Schlachetzki JCM, Antaki D, Lana AJ, Xu X, Chung C, Chai G, Stanley V, Song Q, Newmeyer TF, Nguyen A, O'Brien S, Hoeksema MA, Cao B, Nott A, McEvoy-Venneri J, Pasillas MP, Barton ST, Copeland BR, Nahas S, Van Der Kraan L, Ding Y, Glass CK, Gleeson JG. Somatic mosaicism reveals clonal distributions of neocortical development. Nature. 2022 Apr;604(7907):689-696. doi: 10.1038/s41586-022-04602-7. Epub 2022 Apr 20. PubMed PMID: 35444276; PubMed Central PMCID: PMC9436791.

Wu Z, Zhou J, Nkanga CI, Jin Z, He T, Borum RM, Yim W, Zhou J, Cheng Y, Xu M, Steinmetz NF, Jokerst JV. One-Step Supramolecular Multifunctional Coating on Plant Virus Nanoparticles for Bioimaging and Therapeutic Applications. ACS Appl Mater Interfaces. 2022 Mar 23;14(11):13692-13702. doi: 10.1021/acsami.1c22690. Epub 2022 Mar 8. PubMed PMID: 35258299; PubMed Central PMCID: PMC9159738.

Moinpour M, Fracassi A, Brea RJ, Salvador-Castell M, Pandey S, Edwards MM, Seifert S, Joseph S, Sinha SK, Devaraj NK. Controlling Protein Enrichment in Lipid Sponge Phase Droplets using SNAP-Tag Bioconjugation. Chembiochem. 2022 Mar 4;23(5):e202100624. doi: 10.1002/cbic.202100624. Epub 2022 Jan 19. PubMed PMID: 34936727.

Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE. Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells. Biotechnol Bioeng. 2022 Mar;119(3):963-982. doi: 10.1002/bit.28016. Epub 2022 Jan 5. PubMed PMID: 34953085; PubMed Central PMCID: PMC8821244.

Wu T, Liang Z, Zhang Z, Liu C, Zhang L, Gu Y, Peterson KL, Evans SM, Fu XD, Chen J. PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle. Circulation. 2022 Feb 22;145(8):586-602. doi: 10.1161/CIRCULATIONAHA.121.056666. Epub 2021 Dec 17. PubMed PMID: 34915728; PubMed Central PMCID: PMC8860879.

Gao H, Jin Z, Tang K, Ji Y, Suarez J, Suarez JA, Cunha E Rocha K, Zhang D, Dillmann WH, Mahata SK, Ying W. Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice. J Am Heart Assoc. 2022 Feb 15;11(4):e024561. doi: 10.1161/JAHA.121.024561. Epub 2022 Feb 3. PubMed PMID: 35112881; PubMed Central PMCID: PMC9245808.

Lin HH, Kuang MC, Hossain I, Xuan Y, Beebe L, Shepherd AK, Rolandi M, Wang JW. A nutrient-specific gut hormone arbitrates between courtship and feeding. Nature. 2022 Feb;602(7898):632-638. doi: 10.1038/s41586-022-04408-7. Epub 2022 Feb 9. PubMed PMID: 35140404; PubMed Central PMCID: PMC9271372.

Liang Y, Kaneko K, Xin B, Lee J, Sun X, Zhang K, Feng GS. Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics. Dev Cell. 2022 Feb 7;57(3):398-414.e5. doi: 10.1016/j.devcel.2022.01.004. PubMed PMID: 35134346; PubMed Central PMCID: PMC8842999.

Indralingam CS, Gutierrez-Gonzalez AK, Johns SC, Tsui T, Cannon DT, Fuster MM, Bigby TD, Jennings PA, Breen EC. IL-33/ST2 receptor-dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice. Physiol Rep. 2022 Feb;10(3):e15185. doi: 10.14814/phy2.15185. PubMed PMID: 35150208; PubMed Central PMCID: PMC8839421.

Wu ST, Chen JY, Martin V, Ng R, Zhang Y, Grover D, Greenspan RJ, Aljadeff J, Su CY. Valence opponency in peripheral olfactory processing. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5). doi: 10.1073/pnas.2120134119. PubMed PMID: 35091473; PubMed Central PMCID: PMC8812543.

Mills RH, Dulai PS, Vázquez-Baeza Y, Sauceda C, Daniel N, Gerner RR, Batachari LE, Malfavon M, Zhu Q, Weldon K, Humphrey G, Carrillo-Terrazas M, Goldasich LD, Bryant M, Raffatellu M, Quinn RA, Gewirtz AT, Chassaing B, Chu H, Sandborn WJ, Dorrestein PC, Knight R, Gonzalez DJ. Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity. Nat Microbiol. 2022 Feb;7(2):262-276. doi: 10.1038/s41564-021-01050-3. Epub 2022 Jan 27. PubMed PMID: 35087228; PubMed Central PMCID: PMC8852248.

Gao H, Luo Z, Ji Y, Tang K, Jin Z, Ly C, Sears DD, Mahata S, Ying W. Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice. Nat Commun. 2022 Jan 28;13(1):565. doi:
10.1038/s41467-022-28239-2. PubMed PMID: 35091566; PubMed Central PMCID: PMC8799656.

Kamioka M, Goto Y, Nakamura K, Yokoi Y, Sugimoto R, Ohira S, Kurashima Y, Umemoto S, Sato S, Kunisawa J, Takahashi Y, Domino SE, Renauld JC, Nakae S, Iwakura Y, Ernst PB, Ayabe T, Kiyono H. Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3). doi: 10.1073/pnas.2115230119. PubMed PMID: 35027453; PubMed Central PMCID: PMC8784097.

Moon, J. S. et al. ANT2 drives proinflammatory macrophage activation in obesity. JCI Insight 6, doi:10.1172/jci.insight.147033 (2021).

Diaz-Garcia, S. et al. Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta Neuropathol 142, 985-1001, doi:10.1007/s00401-021-02374-4 (2021).

Ban, Y. et al. Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex. Sci Adv 7, eabh2974, doi:10.1126/sciadv.abh2974 (2021).

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Kroeger, H. et al. ATF6 is essential for human cone photoreceptor development. Proc Natl Acad Sci U S A 118, doi:10.1073/pnas.2103196118 (2021).

Monaghan, C. E., Adamson, S. I., Kapur, M., Chuang, J. H. & Ackerman, S. L. The Clp1 R140H mutation alters tRNA metabolism and mRNA 3' processing in mouse models of pontocerebellar hypoplasia. Proc Natl Acad Sci U S A 118, doi:10.1073/pnas.2110730118 (2021).

Golden, G. J. et al. Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis. mBio 12, e0118121, doi:10.1128/mBio.01181-21 (2021).

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Urresti, J. et al. Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism. Mol Psychiatry, doi:10.1038/s41380-021-01243-6 (2021).

Feng, B. et al. Planar cell polarity signaling components are a direct target of beta-amyloid-associated degeneration of glutamatergic synapses. Sci Adv 7, doi:10.1126/sciadv.abh2307 (2021).

Bogomolovas, J. et al. Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere. EMBO Rep 22, e48018, doi:10.15252/embr.201948018 (2021).

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Sant, V., Som, M., Karkisaval, A. G., Carnahan, P. & Lal, R. Scavenging amyloid oligomers from neurons with silica nanobowls: Implications for amyloid diseases. Biophys J 120, 3329-3340, doi:10.1016/j.bpj.2021.07.002 (2021).

Sapp, V. et al. Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity. Sci Rep 11, 13866, doi:10.1038/s41598-021-92988-1 (2021).

Hoffmann, H. M. et al. The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res 99, 2625-2645, doi:10.1002/jnr.24864 (2021).

Cao, K. J. et al. ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina. Transl Vis Sci Technol 10, 5, doi:10.1167/tvst.10.7.5 (2021).

Maimon, R. et al. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nat Neurosci 24, 1089-1099, doi:10.1038/s41593-021-00864-y (2021).

Ganguly, S. et al. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Cell Mol Gastroenterol Hepatol 12, 891-920, doi:10.1016/j.jcmgh.2021.05.010 (2021).

Lopez-Ramirez, M. A. et al. Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. J Clin Invest 131, doi:10.1172/JCI139570 (2021).

Li, W. et al. Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations. Elife 10, doi:10.7554/eLife.62155 (2021).

Mesarwi, O. A. et al. Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease. Am J Respir Cell Mol Biol 65, 390-402, doi:10.1165/rcmb.2020-0492OC (2021).

Schwaerzer, G. K. et al. Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. Br J Pharmacol, doi:10.1111/bph.15530 (2021).

Navia-Pelaez, J. M. et al. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. J Exp Med 218, doi:10.1084/jem.20202059 (2021).

Kim, W. E. et al. Synthase-Selective Exploration of a Tunicate Microbiome by Activity-Guided Single-Cell Genomics. ACS Chem Biol 16, 813-819, doi:10.1021/acschembio.1c00157 (2021).

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