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Recent Publications

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2021

Moon, J. S. et al. ANT2 drives proinflammatory macrophage activation in obesity. JCI Insight 6, doi:10.1172/jci.insight.147033 (2021).

Diaz-Garcia, S. et al. Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta Neuropathol 142, 985-1001, doi:10.1007/s00401-021-02374-4 (2021).

Ban, Y. et al. Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex. Sci Adv 7, eabh2974, doi:10.1126/sciadv.abh2974 (2021).

Honigfort, D. J., Altman, M. O., Gagneux, P. & Godula, K. Glycocalyx crowding with mucin mimetics strengthens binding of soluble and virus-associated lectins to host cell glycan receptors. Proc Natl Acad Sci U S A 118, doi:10.1073/pnas.2107896118 (2021).

Kroeger, H. et al. ATF6 is essential for human cone photoreceptor development. Proc Natl Acad Sci U S A 118, doi:10.1073/pnas.2103196118 (2021).

Monaghan, C. E., Adamson, S. I., Kapur, M., Chuang, J. H. & Ackerman, S. L. The Clp1 R140H mutation alters tRNA metabolism and mRNA 3' processing in mouse models of pontocerebellar hypoplasia. Proc Natl Acad Sci U S A 118, doi:10.1073/pnas.2110730118 (2021).

Golden, G. J. et al. Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis. mBio 12, e0118121, doi:10.1128/mBio.01181-21 (2021).

Ho, E. V. et al. Reproductive Deficits Induced by Prenatal Antimullerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells. Endocrinology 162, doi:10.1210/endocr/bqab197 (2021).

Urresti, J. et al. Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism. Mol Psychiatry, doi:10.1038/s41380-021-01243-6 (2021).

Feng, B. et al. Planar cell polarity signaling components are a direct target of beta-amyloid-associated degeneration of glutamatergic synapses. Sci Adv 7, doi:10.1126/sciadv.abh2307 (2021).

Bogomolovas, J. et al. Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere. EMBO Rep 22, e48018, doi:10.15252/embr.201948018 (2021).

Wang, L. et al. A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology. Nat Med 27, 1600-1606, doi:10.1038/s41591-021-01443-1 (2021).

Sant, V., Som, M., Karkisaval, A. G., Carnahan, P. & Lal, R. Scavenging amyloid oligomers from neurons with silica nanobowls: Implications for amyloid diseases. Biophys J 120, 3329-3340, doi:10.1016/j.bpj.2021.07.002 (2021).

Sapp, V. et al. Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity. Sci Rep 11, 13866, doi:10.1038/s41598-021-92988-1 (2021).

Hoffmann, H. M. et al. The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res 99, 2625-2645, doi:10.1002/jnr.24864 (2021).

Cao, K. J. et al. ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina. Transl Vis Sci Technol 10, 5, doi:10.1167/tvst.10.7.5 (2021).

Maimon, R. et al. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nat Neurosci 24, 1089-1099, doi:10.1038/s41593-021-00864-y (2021).

Ganguly, S. et al. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Cell Mol Gastroenterol Hepatol 12, 891-920, doi:10.1016/j.jcmgh.2021.05.010 (2021).

Lopez-Ramirez, M. A. et al. Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. J Clin Invest 131, doi:10.1172/JCI139570 (2021).

Li, W. et al. Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations. Elife 10, doi:10.7554/eLife.62155 (2021).

Mesarwi, O. A. et al. Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease. Am J Respir Cell Mol Biol 65, 390-402, doi:10.1165/rcmb.2020-0492OC (2021).

Schwaerzer, G. K. et al. Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. Br J Pharmacol, doi:10.1111/bph.15530 (2021).

Navia-Pelaez, J. M. et al. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. J Exp Med 218, doi:10.1084/jem.20202059 (2021).

Kim, W. E. et al. Synthase-Selective Exploration of a Tunicate Microbiome by Activity-Guided Single-Cell Genomics. ACS Chem Biol 16, 813-819, doi:10.1021/acschembio.1c00157 (2021).

Liao, Z., Gingras, A. R., Lagarrigue, F., Ginsberg, M. H. & Shattil, S. J. Optogenetics-based localization of talin to the plasma membrane promotes activation of beta3 integrins. J Biol Chem 296, 100675, doi:10.1016/j.jbc.2021.100675 (2021).

Liang, Y. et al. Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest 131, doi:10.1172/JCI137689 (2021).

Weijts, B. et al. Endothelial struts enable the generation of large lumenized blood vessels de novo. Nat Cell Biol 23, 322-329, doi:10.1038/s41556-021-00664-3 (2021).

Amar, M. et al. Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling. Mol Psychiatry 26, 3586-3613, doi:10.1038/s41380-021-01052-x (2021).

Zhou, T. et al. Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism. J Mol Biol 433, 166901, doi:10.1016/j.jmb.2021.166901 (2021).

Gleeson, J. et al. A Human 3D neural assembloid model for SARS-CoV-2 infection. Res Sq, doi:10.21203/rs.3.rs-214352/v1 (2021).

Aladesuyi Arogundade, O. et al. Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization. Acta Neuropathol Commun 9, 26, doi:10.1186/s40478-021-01125-6 (2021).

Dorrier, C. E. et al. CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nat Neurosci 24, 234-244, doi:10.1038/s41593-020-00770-9 (2021).

Tang, M. et al. Rapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity. Small 17, e2006050, doi:10.1002/smll.202006050 (2021).

Lu, S. et al. The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Nat Commun 12, 502, doi:10.1038/s41467-020-20768-y (2021).

Li, Y. et al. Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. Elife 10, doi:10.7554/eLife.63509 (2021).

Bali, P., Lozano-Pope, I., Pachow, C. & Obonyo, M. Early detection of tumor cells in bone marrow and peripheral blood in a fastprogressing gastric cancer model. Int J Oncol 58, 388-396, doi:10.3892/ijo.2021.5171 (2021).

Naticchia, M. R., Laubach, L. K., Honigfort, D. J., Purcell, S. C. & Godula, K. Spatially controlled glycocalyx engineering for growth factor patterning in embryoid bodies. Biomater Sci 9, 1652-1659, doi:10.1039/d0bm01434f (2021).

Choi, S. H. et al. Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages. Arterioscler Thromb Vasc Biol 41, e82-e96, doi:10.1161/ATVBAHA.120.315485 (2021).

Yu, H. et al. HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science 371, doi:10.1126/science.abb4309 (2021).

Zhu, Y., Denholtz, M., Lu, H. & Murre, C. Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization. Genes Dev 35, 65-81, doi:10.1101/gad.343475.120 (2021).

Cividini, F. et al. Ncor2/PPARalpha-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function. Diabetes 70, 665-679, doi:10.2337/db20-0779 (2021).

Chai, G. et al. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron 109, 241-256 e249, doi:10.1016/j.neuron.2020.10.035 (2021).

Ghosh, S. G. et al. Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition. Genet Med 23, 524-533, doi:10.1038/s41436-020-01010-y (2021).

Samoudi, M. et al. In situ detection of protein interactions for recombinant therapeutic enzymes. Biotechnol Bioeng 118, 890-904, doi:10.1002/bit.27621 (2021).

Luo, Z. et al. CRIg(+) Macrophages Prevent Gut Microbial DNA-Containing Extracellular Vesicle-Induced Tissue Inflammation and Insulin Resistance. Gastroenterology 160, 863-874, doi:10.1053/j.gastro.2020.10.042 (2021).

Dore, K. & Malinow, R. Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity. Neuroscience 456, 43-49, doi:10.1016/j.neuroscience.2020.02.020 (2021).

2020

Blondelle, J., Biju, A. & Lange, S. The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease. Int J Mol Sci 21, doi:10.3390/ijms21217936 (2020).

Bogomolovas, J. et al. Atypical ALPK2 kinase is not essential for cardiac development and function. Am J Physiol Heart Circ Physiol 318, H1509-H1515, doi:10.1152/ajpheart.00249.2020 (2020).

Boland, B. S. et al. Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses. Sci Immunol 5, doi:10.1126/sciimmunol.abb4432 (2020).

Breuss, M. W. et al. Autism risk in offspring can be assessed through quantification of male sperm mosaicism. Nat Med 26, 143-150, doi:10.1038/s41591-019-0711-0 (2020).

Church, D. C. & Pokorski, J. K. Cell Engineering with Functional Poly(oxanorbornene) Block Copolymers. Angew Chem Int Ed Engl 59, 11379-11383, doi:10.1002/anie.202005148 (2020).

Clark, A. E. et al. Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose. J Virol, doi:10.1128/JVI.02024-20 (2020).

den Hartog, G. et al. Apurinic/Apyrimidinic Endonuclease 1 Restricts the Internalization of Bacteria Into Human Intestinal Epithelial Cells Through the Inhibition of Rac1. Front Immunol 11, 553994, doi:10.3389/fimmu.2020.553994 (2020).

Ghosh, S. G. et al. Recurrent homozygous damaging mutation in TMX2, encoding a protein disulfide isomerase, in four families with microlissencephaly. J Med Genet 57, 274-282, doi:10.1136/jmedgenet-2019-106409 (2020).

Holland, N. D. & Somorjai, I. M. L. The sensory peripheral nervous system in the tail of a cephalochordate studied by serial blockface scanning electron microscopy. J Comp Neurol 528, 2569-2582, doi:10.1002/cne.24913 (2020).

Jimenez Calvente, C., Del Pilar, H., Tameda, M., Johnson, C. D. & Feldstein, A. E. MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury. Mol Ther 28, 653-663, doi:10.1016/j.ymthe.2019.09.013 (2020).

Labarta-Bajo, L. et al. Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection. J Exp Med 217, doi:10.1084/jem.20192276 (2020).

Lange, S., Pinotsis, N., Agarkova, I. & Ehler, E. The M-band: The underestimated part of the sarcomere. Biochim Biophys Acta Mol Cell Res 1867, 118440, doi:10.1016/j.bbamcr.2019.02.003 (2020).

Lee, S. & Gleeson, J. G. Closing in on Mechanisms of Open Neural Tube Defects. Trends Neurosci 43, 519-532, doi:10.1016/j.tins.2020.04.009 (2020).

Lund, S. J. et al. Developmental Immaturity of Siglec Receptor Expression on Neonatal Alveolar Macrophages Predisposes to Severe Group B Streptococcal Infection. iScience 23, 101207, doi:10.1016/j.isci.2020.101207 (2020).

Marsala, M. et al. Spinal parenchymal occupation by neural stem cells after subpial delivery in adult immunodeficient rats. Stem Cells Transl Med 9, 177-188, doi:10.1002/sctm.19-0156 (2020).

Onishi, K. et al. LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication. Proc Natl Acad Sci U S A 117, 18037-18048, doi:10.1073/pnas.1921878117 (2020).

Ozdinler, P. H. et al. Better understanding the neurobiology of primary lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 21, 35-46, doi:10.1080/21678421.2020.1837175 (2020).

Park, G. et al. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease. Cell Rep 31, 107839, doi:10.1016/j.celrep.2020.107839 (2020).

Paschoal, V. A. et al. Positive Reinforcing Mechanisms between GPR120 and PPARgamma Modulate Insulin Sensitivity. Cell Metab 31, 1173-1188 e1175, doi:10.1016/j.cmet.2020.04.020 (2020).

Reilly, S. M. et al. Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab 2, 620-634, doi:10.1038/s42255-020-0217-6 (2020).

Schall, N. et al. Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing. JCI Insight 5, doi:10.1172/jci.insight.135355 (2020).

Sidhwani, P. et al. Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract. Development 147, doi:10.1242/dev.185900 (2020).

Sperk, G. et al. Immunohistochemical distribution of 10 GABAA receptor subunits in the forebrain of the rhesus monkey Macaca mulatta. J Comp Neurol 528, 2551-2568, doi:10.1002/cne.24910 (2020).

Sulaeman, A. et al. Synergistic effect of vascular endothelial growth factor gene inactivation in endothelial cells and skeletal myofibres on muscle enzyme activity, capillary supply and endurance exercise in mice. Exp Physiol 105, 2168-2177, doi:10.1113/EP088924 (2020).

Tang, M. et al. Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. Cell Res 30, 833-853, doi:10.1038/s41422-020-0338-1 (2020).

Teodorof-Diedrich, C. & Spector, S. A. Human Immunodeficiency Virus Type 1 and Methamphetamine-Mediated Mitochondrial Damage and Neuronal Degeneration in Human Neurons. J Virol 94, doi:10.1128/JVI.00924-20 (2020).

Terrey, M. et al. GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis. Elife 9, doi:10.7554/eLife.62731 (2020).

Tsuboi, T. et al. Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis. Elife 9, doi:10.7554/eLife.57814 (2020).

Valentine, K. M., Croft, M. & Shresta, S. Protection against dengue virus requires a sustained balance of antibody and T cell responses. Curr Opin Virol 43, 22-27, doi:10.1016/j.coviro.2020.07.018 (2020).

Wahwah, N. et al. Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity. Sci Rep 10, 19907, doi:10.1038/s41598-020-76958-7 (2020).

Wen, J. et al. CD4(+) T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection. Cell Rep 31, 107566, doi:10.1016/j.celrep.2020.107566 (2020).

Young, R. E. et al. Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching. Dev Cell 53, 73-85 e75, doi:10.1016/j.devcel.2020.02.001 (2020).

Zhang, J. et al. Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function. Circ Res 127, 284-297, doi:10.1161/CIRCRESAHA.119.315539 (2020).

Zhao, P. et al. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science 367, 652-660, doi:10.1126/science.aay0542 (2020).

2019

Wu S, Turner KM, Nguyen N, Raviram R, Erb M, Santini J, Luebeck J, Rajkumar U, Diao Y, Li B, Zhang W, Jameson N, Corces MR, Granja JM, Chen X, Coruh C, Abnousi A, Houston J, Ye Z, Hu R, Yu M, Kim H, Law JA, Verhaak RGW, Hu M, Furnari FB, Chang HY, Ren B, Bafna V, Mischel PS. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019 Nov 20. PMID:31748743

Ackermann BE, Debelouchina GT. Heterochromatin Protein HP1alpha Gelation Dynamics Revealed by Solid-State NMR Spectroscopy. Angew Chem Int Ed Engl 2019;58(19):6300-5. PMCID: PMC6482055.

Aladesuyi Arogundade O, Stauffer JE, Saberi S, Diaz-Garcia S, Malik S, Basilim H, Rodriguez MJ, Ohkubo T, Ravits J. Antisense RNA foci are associated with nucleoli and TDP-43 mislocalization in C9orf72-ALS/FTD: a quantitative study. Acta Neuropathol 2019;137(3):527-30. PMCID: PMC6397670.

Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS. Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metab 2019;30(3):525-38 e8. PMCID: PMC6742496.

Blondelle J, Marrocco V, Clark M, Desmond P, Myers S, Nguyen J, Wright M, Bremner S, Pierantozzi E, Ward S, Esteve E, Sorrentino V, Ghassemian M, Lange S. Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Commun Biol 2019;2:178. PMCID: PMC6509138.

Blondelle J, Tallapaka K, Seto JT, Ghassemian M, Clark M, Laitila JM, Bournazos A, Singer JD, Lange S. Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy. JCI Insight 2019;5. PMCID: PMC6542616.

Courchesne E, Pramparo T, Gazestani VH, Lombardo MV, Pierce K, Lewis NE. The ASD Living Biology: from cell proliferation to clinical phenotype. Mol Psychiatry 2019;24(1):88-107. PMCID: PMC6309606.

Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron 2019;102(2):339-57 e7. PMCID: PMC6548321.

Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. J Lipid Res 2019;60(2):436-45. PMCID: PMC6358287.

Guichard A, Haque T, Bobik M, Xu XS, Klanseck C, Kushwah RBS, Berni M, Kaduskar B, Gantz VM, Bier E. Efficient allelic-drive in Drosophila. Nat Commun 2019;10(1):1640. PMCID: PMC6456580.

Khanna N, Zhang Y, Lucas JS, Dudko OK, Murre C. Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions. Nat Commun 2019;10(1):2771. PMCID: PMC6591236.

Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Borgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman JR, Del Alamo JC, Nigam V. miR-486 is modulated by stretch and increases ventricular growth. JCI Insight 2019.

Lange S, Pinotsis N, Agarkova I, Ehler E. The M-band: The underestimated part of the sarcomere. Biochim Biophys Acta Mol Cell Res 2019.

Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimaki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood 2019;133(3):193-204. PMCID: PMC6337879.

Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet 2019;51(4):705-15. PMCID: PMC6441390.

Ma X, Dewan S, Liu J, Tang M, Miller KL, Yu C, Lawrence N, McCulloch AD, Chen S. 3D printed micro-scale force gauge arrays to improve human cardiac tissue maturation and enable high throughput drug testing. Acta Biomater 2019;95:319-27. PMCID: PMC6584548.

Nair SJ, Yang L, Meluzzi D, Oh S, Yang F, Friedman MJ, Wang S, Suter T, Alshareedah I, Gamliel A, Ma Q, Zhang J, Hu Y, Tan Y, Ohgi KA, Jayani RS, Banerjee PR, Aggarwal AK, Rosenfeld MG. Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly. Nat Struct Mol Biol 2019;26(3):193-203. PMCID: PMC6709854.

Neri T, Hiriart E, van Vliet PP, Faure E, Norris RA, Farhat B, Jagla B, Lefrancois J, Sugi Y, Moore-Morris T, Zaffran S, Faustino RS, Zambon AC, Desvignes JP, Salgado D, Levine RA, de la Pompa JL, Terzic A, Evans SM, Markwald R, Puceat M. Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis. Nat Commun 2019;10(1):1929. PMCID: PMC6486645.

Povero D, Pinatel EM, Leszczynska A, Goyal NP, Nishio T, Kim J, Kneiber D, de Araujo Horcel L, Eguchi A, Ordonez PM, Kisseleva T, Feldstein AE. Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis. JCI Insight 2019;5. PMCID: PMC6675559.

Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB. Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat Commun 2019;10(1):3533. PMCID: PMC6684604.

Tecle E, Reynoso HS, Wang R, Gagneux P. The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival. J Biol Chem 2019;294(31):11910-9. PMCID: PMC6682739.

Yu C, Ma X, Zhu W, Wang P, Miller KL, Stupin J, Koroleva-Maharajh A, Hairabedian A, Chen S. Scanningless and continuous 3D bioprinting of human tissues with decellularized extracellular matrix. Biomaterials 2019;194:1-13. PMCID: PMC6339581.

Zhang Y, Chopp M, Rex CS, Simmon VF, Sarraf ST, Zhang ZG, Mahmood A, Xiong Y. A Small Molecule Spinogenic Compound Enhances Functional Outcome and Dendritic Spine Plasticity in a Rat Model of Traumatic Brain Injury. J Neurotrauma 2019;36(4):589-600. PMCID: PMC6354611.

Zheng B, Lorenzana AO, Ma L. Understanding the axonal response to injury by in vivo imaging in the mouse spinal cord: A tale of two branches. Exp Neurol 2019;318:277-85. PMCID: PMC6588497.

2018

Baumgartel K, Green A, Hornberger D, Lapira J, Rex C, Wheeler DG, Peters M. PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex. Sci Rep 2018;8(1):3895. PMCID: PMC5832851.

Boogerd CJ, Zhu X, Aneas I, Sakabe N, Zhang L, Sobreira DR, Montefiori L, Bogomolovas J, Joslin AC, Zhou B, Chen J, Nobrega MA, Evans SM. Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. Circ Res 2018;123(4):428-42. PMCID: PMC6092109.

Breuss MW, Nguyen A, Song Q, Nguyen T, Stanley V, James KN, Musaev D, Chai G, Wirth SA, Anzenberg P, George RD, Johansen A, Ali S, Zia-Ur-Rehman M, Sultan T, Zaki MS, Gleeson JG. Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome. Am J Hum Genet 2018;103(2):296-304. PMCID: PMC6080764.

Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M. Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis. Ann Rheum Dis 2018;77(11):1636-43. PMCID: PMC6328432.

Chen M, Geoffroy CG, Meves JM, Narang A, Li Y, Nguyen MT, Khai VS, Kong X, Steinke CL, Carolino KI, Elziere L, Goldberg MP, Jin Y, Zheng B. Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Cell Rep 2018;22(13):3587-97. PMCID: PMC5905706.

Choi SH, Wallace AM, Schneider DA, Burg E, Kim J, Alekseeva E, Ubags ND, Cool CD, Fang L, Suratt BT, Miller YI. AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation. JCI Insight 2018;3(16). PMCID: PMC6141166.

Clark AE, Sabalza M, Gordts P, Spector DH. Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms. J Virol 2018;92(6). PMCID: PMC5827393.

De La Zerda DJ, Stokes JA, Do J, Go A, Fu Z, Powell FL. Ibuprofen does not reverse ventilatory acclimatization to chronic hypoxia. Respir Physiol Neurobiol 2018;256:29-35.

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